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DNA binding of thyroid hormone receptors
Biochemical and Biophysical Research Communications, 1975Abstract Thyroid hormone receptors, isolated from rat liver nuclei, bind to purified DNA. By contrast, free triiodothyronine and plasma proteins which bind thyroid hormone do not associate with DNA. Thus, the nuclear localization of thyroid hormone in target tissues may be explained by the association of its receptors with DNA.
K N, MacLeod, J D, Baxter
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Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance
Trends in Endocrinology & Metabolism, 2005Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Two THR genes (A and B), located on different chromosomes, yield four T3-binding isoforms with highly conserved sequences in the DNA- and ligand-binding domains.
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Nongenomic actions of thyroid hormone
Nature Reviews Endocrinology, 2015, Fernando Goglia, Jack L Leonard
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New developments in the diagnosis and treatment of thyroid cancer
Ca-A Cancer Journal for Clinicians, 2013David F Schneider, Herbert Chen
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