Results 1 to 10 of about 26,033 (150)
Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterized by diminished response of the target tissue to thyroid hormone caused, in the majority of cases, by mutation of the thyroid hormone receptor beta (THRβ) gene. Despite elevated
Jae Hee Lee, Eun Young Kim
doaj +3 more sources
Subcellular Distribution of Thyroid Hormone Receptor Beta in Ovarian Cancer [PDF]
International Journal of Molecular Sciences, 2022 Background: Since the most well-known function of thyroid hormone receptors (TRs) relies on their ability to act as ligand-activated transcription factors, their subcellular localization has been recognized to be relevant for their biological meaning.
Bastian Czogalla +2 more
exaly +3 more sources
Extreme resistance to thyroid hormone caused by a novel mosaic thyroid hormone receptor beta mutation. [PDF]
Eur Thyroid JBackground Patients with resistance to thyroid hormone β (RTHβ) show elevated thyroid hormone concentrations with non-suppressed thyroid-stimulating hormone (TSH) concentrations and large phenotypic variability. Triac therapy has been successfully applied in some patients. Mosaic mutations causing mild RTHβ have
van Geest FS +10 more
europepmc +5 more sources
Xenopus laevis alpha and beta thyroid hormone receptors. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1990 The Xenopus laevis genome encodes two genes for the alpha (TR alpha) and two genes for the beta (TR beta) thyroid hormone receptors. The two TR alpha genes closely resemble their rat, human, and chicken counterparts. No alternatively spliced TR alpha cDNA clones were found in the 5' untranslated region (5' UTR).
Yoshio Yaoita, Y B Shi, Brown D D
exaly +4 more sources
A rare mutation of thyroid hormone receptor beta gene in thyroid hormone resistance syndrome [PDF]
Endocrinology, Diabetes & Metabolism Case Reports, 2021 Summary Resistance to thyroid hormone (RTH) is a rare hereditary syndrome with impaired sensitivity to thyroid hormones (TH) and reduced intracellular action of triiodothyronine (T3) caused by genetic variants of TH receptor beta (TRB) or alpha (TRA). RTH type beta (RTHβ) due to dominant negative variants in the TRB gene usually occurs with persistent
Michela Del Prete +6 more
openaire +4 more sources
The Isoforms of Estrogen Receptor Alpha and Beta in Thyroid Cancer
Frontiers in Oncology, 2022 The incidence of thyroid cancer was predominant in women, indicating that the sex hormone may have a role in thyroid cancer development. Generally, the sex hormone exerts its function by binding to the correspondent nuclear receptors. Therefore, aberrant
Zhongqin Gong +10 more
doaj +1 more source
Thyroid hormone and thyroid hormone nuclear receptors: History and present state of art
Endocrine Regulations, 2021 The present review traces the road leading to discovery of L-thyroxine, thyroid hormone (3,5,3´-triiodo-L-thyronine, T3) and its cognate nuclear receptors.
Brtko Julius
doaj +1 more source
Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis. [PDF]
PLoS ONE, 2011 BACKGROUND: Di-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals.
Ouxi Shen +13 more
doaj +1 more source
Oman Medical Journal, 2021 The physiological actions of thyroid hormone (TH) are mediated through TH alpha and TH beta receptors. Resistance to TH (RTH) is characterized by a lack of peripheral tissues’ response to the active form of TH.
Azza Al Shidhani +5 more
doaj +1 more source
THRB (Thyroid Hormone Receptor, Beta) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014 Review on THRB, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Master, A, Nauman, A
openaire +2 more sources