Results 31 to 40 of about 26,033 (150)

Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists [PDF]

Life Sciences, 2016
Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction.Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen to bind to nuclear receptors.In silico screening predicted that both diclofenac and celecoxib has the potential to bind to a number of ...
Mire Zloh, Noelia Perez-Diaz, Leslie Tang, Pryank Patel, Louise S. Mackenzie   +4 more
openaire   +2 more sources

The regulation of thyroid hormone receptor beta genes by thyroid hormone in Xenopus laevis.

Journal of Biological Chemistry, 1992
The mRNA level of the two Xenopus laevis thyroid hormone receptor beta (TR beta) genes is up-regulated in tadpoles and cultured cells by the addition of thyroid hormone (TH). Up-regulation of transcripts of the 5' most exon is detectable 2-3 h before that of full-length TR beta mRNA, strongly suggesting that up-regulation is under transcriptional ...
A, Kanamori, D D, Brown
openaire   +2 more sources

Skeletal effects of nongenomic thyroid hormone receptor beta signaling [PDF]

Journal of Endocrinology, 2019
Thyroid hormone (TH) levels increase rapidly during the prepubertal growth period in mice, and this change is necessary for endochondral ossification of the epiphyses. This effect of TH on epiphyseal chondrocyte hypertrophy is mediated via TRβ1. In addition to its traditional genomic signaling role as a transcription factor, TRβ1 can also exert ...
Richard C, Lindsey, Catrina, Godwin, Subburaman, Mohan   +2 more
openaire   +2 more sources

Hypothyroidism Side Effect in Patients Treated with Sunitinib or Sorafenib: Clinical and Structural Analyses.

PLoS ONE, 2016
Tyrosine kinase inhibitors (TKIs) provide more effective targeted treatments for cancer, but are subject to a variety of adverse effects, such as hypothyroidism. TKI-induced hypothyroidism is a highly complicated issue, because of not only the unrealized
Mao Shu, Xiaoli Zai, Beina Zhang, Rui Wang, Zhihua Lin   +4 more
doaj   +1 more source

Relationship Between Thyroid Dysfunction and Ovarian Cancer

Biomolecules
This review looks at the causes of the association between thyroid dysfunction (hyperthyroidism and hypothyroidism) and ovarian cancer (OC) risk. Epidemiological data have revealed that thyroid dysfunction, particularly hyperthyroidism, is associated ...
Justyna Gogola-Mruk, Aleksandra Sirek, Izabela Kumor, Gabriela Wojtaszek, Klaudia Roszak, Karolina Kulig, Anna Ptak   +6 more
doaj   +1 more source

Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm

Journal of Lipid Research, 2009
Respiratory failure is a major cause of mortality during septic shock and is due in part to decreased ventilatory muscle contraction. Ventilatory muscles have high energy demands; fatty acid (FA) oxidation is an important source of ATP.
Kenneth R. Feingold, Arthur Moser, Sophie M. Patzek, Judy K. Shigenaga, Carl Grunfeld   +4 more
doaj   +1 more source

Genome-Wide Binding Patterns of Thyroid Hormone Receptor Beta

PLoS ONE, 2014
Thyroid hormone (TH) receptors (TRs) play central roles in metabolism and are major targets for pharmaceutical intervention. Presently, however, there is limited information about genome wide localizations of TR binding sites. Thus, complexities of TR genomic distribution and links between TRβ binding events and gene regulation are not fully ...
Stephen Ayers, Michal Piotr Switnicki, Anusha Angajala, Jan Lammel, Anithachristy S Arumanayagam, Paul Webb   +5 more
openaire   +4 more sources

Evaluation of cardiovascular autonomic reactivity by cold pressor test in thyroid dysfunction in adults: A prospective case-control study

National Journal of Physiology, Pharmacy and Pharmacology, 2017
Background: Changes, in thyroid status, have pronounced effects on cardiovascular system reflecting autonomic dysfunction and increased morbidity. Exact interaction between autonomic nervous activity and thyroid hormones is controversial.
Sunita Milind Tiwale, Padmaja Rajey Desai   +1 more
doaj   +1 more source

Identification of a Thyroid Hormone Binding Site in Hsp90 with Implications for Its Interaction with Thyroid Hormone Receptor Beta

ACS Omega, 2022
While many proteins are known clients of heat shock protein 90 (Hsp90), it is unclear whether the transcription factor, thyroid hormone receptor beta (TRb), interacts with Hsp90 to control hormonal perception and signaling. Higher Hsp90 expression in mouse fibroblasts was elicited by the addition of triiodothyronine (T3). T3 bound to Hsp90 and enhanced
Lu Fan, Anusha Kishore, Linda Jansen-Olliges, Dahua Wang, Frank Stahl, Olympia Ekaterini Psathaki, Jennifer Harre, Athanasia Warnecke, Julia Weder, Matthias Preller, Carsten Zeilinger   +10 more
openaire   +3 more sources

Identification of a novel subgroup of endometrial cancer patients with loss of thyroid hormone receptor beta expression and improved survival

BMC Cancer, 2020
Background Endometrial cancer (EC) is the most common gynecologic cancer in women, and the incidence of EC has increased by about 1% per year in the U. S over the last 10 years.
Daniel G. Piqué, John M. Greally, Jessica C. Mar   +2 more
doaj   +1 more source