Results 261 to 270 of about 121,615 (309)

Nuclear Receptors for Thyroid Hormone

Journal of Endocrinological Investigation, 1978
The concept that thyroxine (T4) or triiodothyronine (T3) might act by modification of nuclear RNA synthesis was advanced by Tata in the early 1960’s (Tata, Ernster, and Suranyi, 1962). He reported that T4 induced new RNA and protein synthesis, and indicated later that the earliest observable effect was on the function of nuclear magnesium-dependent ...
L J, DeGroot, S, Refetoff, J, Bernal, P A, Rue, A H, Coleoni   +4 more
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Thyroid Hormone Receptor Gene Knockouts

Trends in Endocrinology & Metabolism, 1998
The thyroid hormone receptor genes, TRalpha and TRbeta, differ in developmental expression and tissue distribution. TRbeta knockout mice have goiter, elevated thyroid hormone and TSH levels, and a functional auditory defect. In contrast, mice with TRalpha 1/alpha2 inactivation have thyroid hypoplasia, low serum thyroid hormone levels, growth arrest and
J H, Hsu, G A, Brent
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Thyroid Hormone Receptors

1995
Thyroid hormones notably Triiodothyronine (T3) and thyroxine (T4) play important roles in many biological processes in all vertebrates (De Groot et al, 1984). They affect growth, development and differentiation, metabolism and homeostasis. A particularly striking observation was made by Gudernatsch in the early part of this century that thyroid ...
F. Javier Piedrafita, Magnus Pfahl
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Thyroid Hormone Receptors

2010
Thyroid hormone promotes a diverse range of developmental, neurological and metabolic functions in vertebrate species. Human thyroid disorders result in a correspondingly wide range of disease symptoms. The functions of thyroid hormone are mediated by a small group of thyroid hormone receptors encoded by two conserved genes.
BjÖRn VennstrÖM, Hong Liu, Douglas Forrest   +2 more
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Thyroid hormone receptors and reproduction

Journal of Reproductive Immunology, 2011
Thyroid disorders have a great impact on fertility in both sexes. Hyperthyroidism and hypothyroidism cause changes in sex hormone-binding globulin (SHBG), prolactin, gonadotropin-releasing hormone, and sex steroid serum levels. In females, thyroid hormones may also have a direct effect on oocytes, because it is known that specific binding sites for ...
Ralf, Dittrich, Matthias W, Beckmann, Patricia G, Oppelt, Inge, Hoffmann, Laura, Lotz, Torsten, Kuwert, Andreas, Mueller   +6 more
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Thyroid Hormone Receptors

Comprehensive Physiology, 1998
Abstract The sections in this article are: 3,5,3′ Triiodo‐ L ‐Thyronine (T 3 ) Receptors: Overview
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Selective Thyroid Hormone Receptor Modulators

Current Topics in Medicinal Chemistry, 2003
Thyroid hormone regulates many important processes in vertebrates. Analysis of the symptoms that accompany hypo- and hyperthyroidism, the most common disorders of the thyroid, suggests that there are certain desirable biological effects brought about by an excess or deficiency of thyroid hormone, and that selective thyroid hormone receptor modulators ...
Hikari A I, Yoshihara, Thomas S, Scanlan
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Thyroid Hormone Receptors and Responses

1979
Publisher Summary This chapter discusses the responses of thyroid hormone receptors. The thyroid hormone receptor is unique in that it is an intrinsic chromosomal nonhistone protein known to be involved in the regulation of the expression of specific genes. These receptors are bound to chromatin in the absence or the presence of thyroid hormone. They
J D, Baxter, N L, Eberhardt, J W, Apriletti, L K, Johnson, R D, Ivarie, B S, Schachter, J A, Morris, P H, Seeburg, H M, Goodman, K R, Latham, J R, Polansky, J A, Martial   +11 more
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