Results 261 to 270 of about 67,031 (307)

Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology

Fertility and Sterility, 2011
To study the expression, distribution, and function of thyroid-stimulating hormone receptor (TSHR) and thyroid hormone receptors (TR) α1, α2, and β1 in human endometrium.Experimental clinical study.University hospital.31 fertile women.Endometrial biopsy samples obtained throughout the menstrual cycle.Real-time reverse transcriptase polymerase chain ...
Lusine Aghajanova, Anneli Stavreus-Evers, Britt-Marie Landgren   +2 more
exaly   +3 more sources

Nuclear receptors for thyroid hormone

Journal of Endocrinological Investigation, 1978
The concept that thyroxine (T4) or triiodothyronine (T3) might act by modification of nuclear RNA synthesis was advanced by Tata in the early 1960’s (Tata, Ernster, and Suranyi, 1962). He reported that T4 induced new RNA and protein synthesis, and indicated later that the earliest observable effect was on the function of nuclear magnesium-dependent ...
L J, DeGroot, S, Refetoff, J, Bernal, P A, Rue, A H, Coleoni   +4 more
openaire   +4 more sources

Thyroid hormone receptors and reproduction

Journal of Reproductive Immunology, 2011
Thyroid disorders have a great impact on fertility in both sexes. Hyperthyroidism and hypothyroidism cause changes in sex hormone-binding globulin (SHBG), prolactin, gonadotropin-releasing hormone, and sex steroid serum levels. In females, thyroid hormones may also have a direct effect on oocytes, because it is known that specific binding sites for ...
Ralf, Dittrich, Matthias W, Beckmann, Patricia G, Oppelt, Inge, Hoffmann, Laura, Lotz, Torsten, Kuwert, Andreas, Mueller   +6 more
openaire   +2 more sources

A structural role for hormone in the thyroid hormone receptor

Nature, 1995
The crystal structure of the rat alpha 1 thyroid hormone receptor ligand-binding domain bound with a thyroid hormone agonist reveals that ligand is completely buried within the domain as part of the hydrophobic core. In addition, the carboxy-terminal activation domain forms an amphipathic helix, with its hydrophobic face constituting part of the ...
R L, Wagner, J W, Apriletti, M E, McGrath, B L, West, J D, Baxter, R J, Fletterick   +5 more
openaire   +2 more sources

Thyroid Hormone Receptors and Responses

1979
Publisher Summary This chapter discusses the responses of thyroid hormone receptors. The thyroid hormone receptor is unique in that it is an intrinsic chromosomal nonhistone protein known to be involved in the regulation of the expression of specific genes. These receptors are bound to chromatin in the absence or the presence of thyroid hormone. They
J D, Baxter, N L, Eberhardt, J W, Apriletti, L K, Johnson, R D, Ivarie, B S, Schachter, J A, Morris, P H, Seeburg, H M, Goodman, K R, Latham, J R, Polansky, J A, Martial   +11 more
openaire   +2 more sources

Thyroid Hormone Receptors

1995
Thyroid hormones notably Triiodothyronine (T3) and thyroxine (T4) play important roles in many biological processes in all vertebrates (De Groot et al, 1984). They affect growth, development and differentiation, metabolism and homeostasis. A particularly striking observation was made by Gudernatsch in the early part of this century that thyroid ...
F. Javier Piedrafita, Magnus Pfahl
openaire   +1 more source

Mild resistance to thyroid hormone with a truncated thyroid hormone receptor ß

Experimental and Clinical Endocrinology & Diabetes, 2009
Recent studies have revealed mutations in the thyroid hormone receptor beta (TR beta) gene as a cause of the most cases of the thyroid hormone resistance syndrome. We have identified a novel nonsense mutation in codon 449 in the 3' end of exon 10 in the TR beta gene in a 16-year-old male patient with generalized resistance to thyroid hormone who also ...
M, Taniyama, S, Kusano, Y, Miyoshi, H, Nakamura, M, Kaihara, T, Tobe, M, Tomita, T, Katagiri, Y, Ban   +8 more
openaire   +2 more sources

Thyroid Hormone Receptors

2010
Thyroid hormone promotes a diverse range of developmental, neurological and metabolic functions in vertebrate species. Human thyroid disorders result in a correspondingly wide range of disease symptoms. The functions of thyroid hormone are mediated by a small group of thyroid hormone receptors encoded by two conserved genes.
BjÖRn VennstrÖM, Hong Liu, Douglas Forrest   +2 more
openaire   +1 more source

Resistance to Thyroid Hormone in a Patient Without Thyroid Hormone Receptor Mutations

Thyroid, 2002
Resistance to thyroid hormone (RTH) is a clinical syndrome characterized by elevated serum thyroid hormone (TH) levels, unsuppressed thyrotropin (TSH) levels, and tissue hyposensitivity to TH. In almost all cases, the genetic basis of RTH lies in mutation of one of the two TH receptor beta (TRbeta) alleles. Recently, patients from several families with
S, Parikh, S, Ando, A, Schneider, M C, Skarulis, N J, Sarlis, P M, Yen   +5 more
openaire   +2 more sources

Thyroid Hormone Receptors

Comprehensive Physiology, 1998
Abstract The sections in this article are: 3,5,3′ Triiodo‐ L ‐Thyronine (T 3 ) Receptors: Overview
openaire   +1 more source