Results 261 to 270 of about 1,086,464 (298)

Mild resistance to thyroid hormone with a truncated thyroid hormone receptor ß

Experimental and Clinical Endocrinology & Diabetes, 2009
Recent studies have revealed mutations in the thyroid hormone receptor beta (TR beta) gene as a cause of the most cases of the thyroid hormone resistance syndrome. We have identified a novel nonsense mutation in codon 449 in the 3' end of exon 10 in the TR beta gene in a 16-year-old male patient with generalized resistance to thyroid hormone who also ...
M, Taniyama, S, Kusano, Y, Miyoshi, H, Nakamura, M, Kaihara, T, Tobe, M, Tomita, T, Katagiri, Y, Ban   +8 more
openaire   +2 more sources

Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Thyroid hormone acts via receptor subtypes (TRα1, TRβ1, TRβ2) with differing tissue distributions, encoded by distinct genes (THRA, THRB). THRB mutations cause a disorder with central (hypothalamic-pituitary) resistance to thyroid hormone action with markedly elevated thyroid hormone and normal TSH levels.This review describes the clinical features ...
Schoenmakers, N, Moran, C, Peeters, Robin, Visser, Theo, Gurnell, M, Chatterjee, K   +5 more
openaire   +2 more sources

Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action

American Journal of Physiology-Endocrinology and Metabolism, 2003
Isoforms of the thyroid hormone receptor ( TR) α and TRβ genes mediate thyroid hormone action. How TR isoforms modulate tissue-specific thyroid hormone (TH) action remains largely unknown. The steroid receptor coactivator-1 (SRC-1) is among a group of transcriptional coactivator proteins that bind to TRs, along with other members of the nuclear ...
Sadow, P.M., Chassande, Olivier, Gauthier, K., Samarut, Jacques, Xu, J., O'Malley, B.W., Weiss, R.E.   +6 more
openaire   +3 more sources

Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance

Trends in Endocrinology & Metabolism, 2005
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Two THR genes (A and B), located on different chromosomes, yield four T3-binding isoforms with highly conserved sequences in the DNA- and ligand-binding domains.
openaire   +2 more sources

Thyroid Hormone Receptors

2001
Dressel, U., Baniahmad, A.
openaire   +2 more sources

Thyroid Hormone Transporters

Endocrine Reviews, 2020
Stefan Groeneweg, Heike Heuer, Robin Peeters   +2 more
exaly  

Thyroid Hormone Receptors

2021
Maria Laura Tanda, Silvia Ippolito
openaire   +1 more source

A Comprehensive Review of Thyroid Hormone Metabolism in the Gut and Its Clinical Implications

Thyroid, 2023
Eveline Bruinstroop, Anne van der Spek, Anita Boelen   +2 more
exaly  

Thyroid Hormone Disruption by Organophosphate Esters Is Mediated by Nuclear/Membrane Thyroid Hormone Receptors: In Vitro, In Vivo, and In Silico Studies

Environmental Science & Technology, 2022
Na Li, Yuanzheng Zhai, Haiyang Chen
exaly  

A Historical Reflection on Scientific Advances in Understanding Thyroid Hormone Action

Thyroid, 2023
Gregory Brent
exaly