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Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013Thyroid hormone acts via receptor subtypes (TRα1, TRβ1, TRβ2) with differing tissue distributions, encoded by distinct genes (THRA, THRB). THRB mutations cause a disorder with central (hypothalamic-pituitary) resistance to thyroid hormone action with markedly elevated thyroid hormone and normal TSH levels.This review describes the clinical features ...
Schoenmakers, N +5 more
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Promotion by thyroid hormone of cytoplasm-to-nucleus shuttling of thyroid hormone receptors
Steroids, 2008Confocal microscopy and cell fractionation studies have revealed the residence of nuclear thyroid hormone receptors (TR) in cytoplasm. Treatment of cells with the hormone (L-thyroxine or 3,5,3'-triiodo-L-thyronine, T(3)) results in shuttling of TR into the nuclear compartment. Confocal microscopy has also disclosed that TR in the nuclear compartment is
Paul J, Davis +2 more
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Nuclear thyroid hormone receptors: ontogeny and thyroid hormone effects in sheep
American Journal of Physiology-Endocrinology and Metabolism, 1989To investigate the mechanism(s) responsible for the paucity of fetal thyroid hormone effects, thyroid hormone nuclear receptor (T3NR) binding characteristics were quantified in liver and brain of fetal and neonatal sheep. Maximal binding capacities [MBC; mean +/- SE fmol 3,5,3'-triiodothyronine (T3)/mg DNA] in liver increased from values of 68 +/- 14 ...
D, Polk +3 more
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Thyroid hormone receptors in perennibranchiate amphibians
The International Journal of Developmental Biology, 1997Thyroid hormone has long been known to induce metamorphosis in amphibians. The understanding of the molecular steps controlling the completion of metamorphosis has nevertheless been hampered by the complexity of this event. The comparison of organisms in which metamorphosis does or does not occur, may provide clues into the molecular cascade that ...
R, Safi, A, Deprez, V, Laudet
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DNA binding of thyroid hormone receptors
Biochemical and Biophysical Research Communications, 1975Abstract Thyroid hormone receptors, isolated from rat liver nuclei, bind to purified DNA. By contrast, free triiodothyronine and plasma proteins which bind thyroid hormone do not associate with DNA. Thus, the nuclear localization of thyroid hormone in target tissues may be explained by the association of its receptors with DNA.
K N, MacLeod, J D, Baxter
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Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance
Trends in Endocrinology & Metabolism, 2005Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Two THR genes (A and B), located on different chromosomes, yield four T3-binding isoforms with highly conserved sequences in the DNA- and ligand-binding domains.
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