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Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance
Trends in Endocrinology & Metabolism, 2005Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Two THR genes (A and B), located on different chromosomes, yield four T3-binding isoforms with highly conserved sequences in the DNA- and ligand-binding domains.
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The Thyroid Hormone Receptors: Molecular Basis of Thyroid Hormone Resistance
Hormone Research, 1992Major progress has been achieved in the mechanism of action of thyroid hormones thanks to the identification of the T3 receptor as the product of the proto-oncogene c-erbA. Recognition of subsets of receptors with and without T3-binding properties and of the interaction of different receptors with each other leads to new insights in cell regulation and
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New developments in the diagnosis and treatment of thyroid cancer
Ca-A Cancer Journal for Clinicians, 2013David F Schneider, Herbert Chen
exaly

