Results 261 to 270 of about 87,840 (306)
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Trends in Biochemical Sciences, 1982
Abstract The isolation and analysis of the transferrin receptor has been greatly aided by the use of monoclonal antibodies. The receptor is a disulphide-linked homo-dimer which spans the membrane and binds two molecules of transferrin. Controlling genes for this receptor in humans have been mapped to chromosome 3 using cell hybrids.
Roland Newman +4 more
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Abstract The isolation and analysis of the transferrin receptor has been greatly aided by the use of monoclonal antibodies. The receptor is a disulphide-linked homo-dimer which spans the membrane and binds two molecules of transferrin. Controlling genes for this receptor in humans have been mapped to chromosome 3 using cell hybrids.
Roland Newman +4 more
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Diffusion of transferrin receptor clusters
Biophysical Chemistry, 1998Two dimensional motion of membrane receptors provides a mechanism for interaction among receptors in the plane of the membrane. In some cases the lateral diffusion leads to formation of clusters which may also be mobile. We have used image cross-correlation (ICCS) spectroscopy technique to measure the translational motion of transferrin receptors in ...
M, Srivastava, N O, Petersen
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Bacterial transferrin and lactoferrin receptors
Trends in Microbiology, 1996Pathogenic members of the Neisseriaceae and Pasteurellaceae express outer-membrane receptor proteins involved in the direct assimilation of iron from the host glycoproteins transferrin and lactoferrin. The critical requirement of iron for growth suggests that this function is an important component of colonization and infection. A model describing this
S D, Gray-Owen, A B, Schryvers
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Transferrin receptor in oral tumors
International Journal of Oral and Maxillofacial Surgery, 1994The transferrin receptor (TfR) appears in vigorously proliferating cells. We did an immunohistochemical study of TfR in oral tissues and a quantitative analysis by flow cytometry of TfR in a cancer cell line after an anticancer drug treatment. TfR was found in the parabasal and basal layers of the normal epithelium, but rarely in benign tumors ...
T, Miyamoto +3 more
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Lymphoid receptors for transferrin
1987Publisher Summary Transferrin receptors present on the cell surface interact with this serum protein and provide a way in which iron can be specifically and vectorially transported through the plasma membrane. The transferrin receptor has proved to be an extremely useful system for the characterization of ligand/receptor interactions, receptor ...
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Transferrin receptor: Its biological significance
The Journal of Membrane Biology, 1985The TR is a vital surface component which has been demonstrated to be involved in processes critical for cell metabolism and growth. This review has attempted to briefly touch on the more well understood aspects of study of the TR. These aspects include the biochemical characterization of the TR and the functional studies concerning the central role of
W S, May, P, Cuatrecasas
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Transferrin receptors in injured brain
Acta Neuropathologica, 1990Recent studies have demonstrated the presence of transferrin receptors (Tf-R) in the central nervous system. The present study of Wistar rats with experimentally induced brain injuries, using immunohistochemistry at the light microscopy level, demonstrated the presence of Tf-R in regenerated endothelial cells, reactive astrocytes and in other cells ...
T, Orita +6 more
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Transferrin and Transferrin Receptor Function in Brain Barrier Systems
Cellular and Molecular Neurobiology, 20001. Iron (Fe) is an essential component of virtually all types of cells and organisms. In plasma and interstitial fluids, Fe is carried by transferrin. Iron-containing transferrin has a high affinity for the transferrin receptor, which is present on all cells with a requirement for Fe.
T, Moos, E H, Morgan
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Regulation of transferrin receptor 2 protein levels by transferrin
Blood, 2004AbstractTransferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis. In this study, iron-responsive regulation of TfR2 at the protein level was examined in vitro and in vivo.
Aeisha, Robb, Marianne, Wessling-Resnick
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Expression of Human Transferrin Receptor
2015Note: Author address: Swiss Institute for Experimental Cancer Research, Epalinges s/Lausanne.
B, Neupert +7 more
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