Results 61 to 70 of about 185,186 (308)

Role of endocannabinoid CB1 receptors in Streptozotocin-induced uninephrectomised Wistar rats in diabetic nephropathy

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background The endocannabinoid CB1 receptor is known to have protective effects in kidney disease. The aim of the present study is to evaluate the potential agonistic and antagonistic actions and to determine the renoprotective potential of CB1 receptors
Jayarami Reddy Medapati, Deepthi Rapaka, Veera Raghavulu Bitra, Santhosh Kumar Ranajit, Girija Sankar Guntuku, Annapurna Akula   +5 more
doaj   +1 more source

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice [PDF]

, 2006
Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair.
Addison CL, Armstrong DA, Baggiolini M, Barbara Walzog, Bazzoni F, Benelli R, Bernardini G, Bohnsack JF, Brandes ME, Cacalano G, Choudhuri R, Devalaraja RM, Dewald B, Dubravec DB, Gasperini S, Gaudry M, Grant DS, Grenier A, Grotendorst GR, Harada H, Heiple JM, Ikematsu S, Iruela-Arispe ML, John A, Jürgen Schymeinsky, Karin Scharffetter-Kochanek, Kreis C, Kullander K, Liu XH, Loukinova E, Matzner Y, Muramaki M, Niiro H, Oda N, Pertovaara L, Ramchandran R, Roberts AB, Ruth Schruefer, Sang QX, Sato W, Scapini P, Scharffetter-Kochanek K, Schruefer R, Sehgal I, Semenza GL, Shapiro SD, Silke Sulyok, Takada T, Takada T, Tasiemski A, Thorsten Peters, Triebel S, Walzog B, Wang SC, Willeke T, Yoshida S   +55 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transforming Growth Factor β Receptors and p27kip in Thyroid Carcinoma [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 1999
To investigate the role of cell cycle regulators in the pathogenesis of papillary carcinoma of the thyroid.Resistance to transforming growth factor beta-mediated inhibition is a well-known pathogenic mechanism in epithelial neoplasias. In a retrospective study, the expression of transforming growth factor beta receptors types I and II, cyclin D1, and ...
C A, Muro-Cacho, T, Muñoz-Antonia, S, Livingston, D, Klotch   +3 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

GROWTH FACTOR AND ADIPOKINE RECEPTORS IN PATHOGENESIS AND PROGNOSIS OF ENDOMETRIAL CANCER IN PATIENTS WITH METABOLIC SYNDROME

Сибирский онкологический журнал, 2016
The role of growth factor receptors (insulin-like growth factor and transforming growth factor-beta) and adipokine receptors (leptin and adiponectin) in pathogenesis of endometrial cancer under conditions of metabolic syndrome is discussed ...
N. V. Yunusova, I. V. Kondakova, L. А. Kolomiets, А. L. Chernyshova, Е. V. Shanshashvili   +4 more
doaj  

Insights into Bone Morphogenetic Protein—(BMP-) Signaling in Ocular Lens Biology and Pathology

Cells, 2021
Bone morphogenetic proteins (BMPs) are a diverse class of growth factors that belong to the transforming growth factor-beta (TGFβ) superfamily. Although originally discovered to possess osteogenic properties, BMPs have since been identified as critical ...
Daisy Y. Shu, Frank J. Lovicu
doaj   +1 more source

TGFBRAP1 (transforming growth factor, beta receptor associated protein 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on TGFBRAP1 (transforming growth factor, beta receptor associated protein 1), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. [PDF]

, 2019
The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1 Col2 mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular ...
Baek, Jongseung, Chun, Hyelim, Lopez, Noah, Lyons, Karen M, Razavi, Peyman, Sadik, Joshua Elyahu, Shirazyan, Anna, Wang, Weiguang   +7 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source