Results 41 to 50 of about 185,186 (308)
Toxins, 2023 Research into various proteins capable of blocking metabolic pathways has improved the detection and treatment of multiple pathologies associated with the malfunction and overexpression of different metabolites.
Salvador Dueñas +11 more
doaj +1 more source
TGFBR2 (Transforming Growth Factor, Beta Receptor II (70/80kDa)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014 Review on TGFBR2, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Sivadas, VP, Kannan, S
openaire +2 more sources
Thrombospondin 1 in Metabolic Diseases
Frontiers in Endocrinology, 2021 The thrombospondin family comprises of five multifunctional glycoproteins, whose best-studied member is thrombospondin 1 (TSP1). This matricellular protein is a potent antiangiogenic agent that inhibits endothelial migration and proliferation, and ...
Linda S. Gutierrez, Jovita Gutierrez
doaj +1 more source
A mathematical model quantifies proliferation and motility effects of TGF--$\beta$ on cancer cells [PDF]
, 2008 Transforming growth factor (TGF) $\beta$ is known to have properties of both a tumor suppressor and a tumor promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell--cell adhesion.
Arteaga, Carlos L. +6 more
core +3 more sources
The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example
The Scientific World Journal, 2011 Seven transmembrane G protein—coupled receptors are among the most common in biology and they transduce cellular signals from a plethora of hormones. As well as their own well-characterized signaling pathways, they can also transactivate tyrosine kinase ...
Peter J. Little +3 more
doaj +1 more source
Diagnostics, 2021 Congenital diaphragm hernia (CDH) is a congenital disease that occurs during prenatal development. Although the morbidity and mortality rate is rather significant, the pathogenesis of CDH has been studied insignificantly due to the decreased ...
Ricards Kaulins +3 more
doaj +1 more source
Cytokines of Birds: Conserved Functions [PDF]
, 2001 Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F. +4 more
core +1 more source
TGF-Beta in the Natural History of Prostate Cancer
Acta Clinica Croatica, 2019 All transforming growth factors beta (TGFß) are cytokines that regulate several cellular functions such as cell growth, differentiation and motility. They may also have a role in immunosuppression. Their role is important for normal prostate development.
Jamal Ahel +3 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1999 The transforming growth factor-beta (TGFbeta) signaling pathway is one important player in the regulation of extracellular matrix turnover and cell proliferation in epithelial regeneration. We used cerulein-induced pancreatitis in rats as a model to investigate the regulation of TGFbeta receptor type I and type II expression on protein and messenger ...
Menke, Andre +5 more
openaire +2 more sources
TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves [PDF]
, 2006 During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important control in vivo.
D'Antonio, M +6 more
core