Results 21 to 30 of about 185,186 (308)
EGF and TGF-β1 effects on thyroid function [PDF]
, 2011 Normal epithelial thyroid cells in culture are inhibited by TGF-β1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-β responsiveness could be due to a reduced expression of TGF-β receptors, as
Gabriella Mincione +7 more
core +2 more sources
New targets for resolution of airway remodeling in obstructive lung diseases. [PDF]
, 2018 Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD).
Deshpande, Deepak A. +2 more
core +2 more sources
Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis [PDF]
, 2016 Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage.
Bartholin, Laurent +5 more
core +1 more source
Intracellular trafficking of transforming growth factor β receptors [PDF]
Acta Biochimica et Biophysica Sinica, 2018 Transforming growth factor β (TGFβ) family members signal via heterotetrameric complexes of type I (TβRI) and type II (TβRII) dual specificity kinase receptors. The availability of the receptors on the cell surface is controlled by several mechanisms.
Ihor, Yakymovych +2 more
openaire +2 more sources
Targeting transforming growth factor-β receptors in pulmonary hypertension [PDF]
European Respiratory Journal, 2020 The transforming growth factor-β (TGF-β) superfamily includes several groups of multifunctional proteins that form two major branches, namely the TGF-β–activin–nodal branch and the bone morphogenetic protein (BMP)–growth differentiation factor (GDF) branch.
Christophe Guignabert, Marc Humbert
openaire +3 more sources
The World Journal of Men's Health, 2020 Purpose: To examine the therapeutic effect of Vactosertib, a small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor (activin receptor-like kinase-5, ALK5), in an experimental model of Peyronie’s disease (PD) and determining ...
Kang-Moon Song +11 more
doaj +1 more source
Scientific Reports, 2023 In the repair of injury, some transforming growth factor- $$\beta$$ β s (TGF- $$\beta$$ β s) and platelet-derived growth factors (PDGFs) bind to fibroblast receptors as ligands and cause the differentiation of fibroblasts into myofibroblasts.
Fatemeh Bahram Yazdroudi, Alaeddin Malek
doaj +1 more source
Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]
, 2018 The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M +3 more
core +2 more sources
Veterinary Research, 2011 H9N2 influenza virus is endemic in many Asian countries and is regarded as a candidate for the next human pandemic. Knowledge of the induction of inflammatory responses and toll-like receptors (TLRs) in chickens infected with H9N2 is limited.
Nang Nguyen +5 more
doaj +1 more source
An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. [PDF]
PLoS ONE, 2015 The epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of head and neck squamous cell carcinomas (HNSCC), and molecularly targeted therapy against the EGFR with the monoclonal antibody cetuximab modestly increases overall ...
Emily K Kleczko +10 more
doaj +1 more source