Results 31 to 40 of about 185,186 (308)

Biological activity differences between TGF-β1 and TGF-β3 correlate with differences in the rigidity and arrangement of their component monomers [PDF]

, 2014
[Image: see text] TGF-β1, -β2, and -β3 are small, secreted signaling proteins. They share 71–80% sequence identity and signal through the same receptors, yet the isoform-specific null mice have distinctive phenotypes and are inviable.
Andrew P. Hinck, Archer S. J., Archer S. J., Baardsnes J., Baker S. M., Bandyopadhyay B., Biernacka A., Bocharov E. V., Bocharov E. V., Cheifetz S., Daopin S., Deep S., Delaglio F., Eghbalnia H. R., Freedberg D. I., Gato A., Goddard T. D., Groppe J., Grutter C., Grzesiek S., Grzesiek S., Hall B. E., Hart P. J., Hinck A. P., Hinck A. P., Huang T., Kay L. E., Kay L. E., Kulkarni A. B., Liu Q., Loeys B. L., Lopez-Casillas F., Marley J., Massague J., Massague J., Massague J., Mendoza V., Mittl P. R., Moustakas A., Munoz V., Munoz V., Nilsen-Hamilton M., Pellaud J., Proetzel G., Qian S. W., Radaev S., Sanford L. P., Schlunegger M. P., Schor S. L., Seth L. Schor, Shah M., Shi Y., Shull M. M., Tao Huang, Taya Y., Tudela C., Wittekind M., Wrana J. L., Wrana J. L., Yang L. T., Zou Z., Zuniga J. E.   +61 more
core   +2 more sources

Development of Normal and Cleft Palate: A Central Role for Connective Tissue Growth Factor (CTGF)/CCN2

Journal of Developmental Biology, 2018
Development of the palate is the result of an organized series of events that require exquisite spatial and temporal regulation at the cellular level. There are a myriad of growth factors, receptors and signaling pathways that have been shown to play an ...
Joseph T. Tarr, Alex G. Lambi, James P. Bradley, Mary F. Barbe, Steven N. Popoff   +4 more
doaj   +1 more source

Sex differences in the pituitary TGFβ1 system: the role of TGFβ1 in prolactinoma development [PDF]

, 2019
Prolactinomas are the most frequent functioning pituitary adenomas, and sex differences in tumor size, behavior and incidence have been described. These differences have been associated with earlier diagnosis in woman, as well as with serum estradiol ...
Abeledo Machado, Alejandra Inés, Camilletti, María Andrea, Diaz, Graciela Susana, Faraoni, Erika Yanil, Ratner, Laura Daniela, Recouvreux, Maria Victoria, Rulli, Susana Beatriz   +6 more
core   +1 more source

Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma

World Journal of Surgical Oncology, 2007
Precursors and preinvasive lesions of the breast include atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and lobular neoplasia (LN).
Zografos George C, Sergentanis Theodoros N, Zagouri Flora   +2 more
doaj   +1 more source

Three-Dimensional Culture of Human Dental Pulp Tissue: A Preliminary Experimental In Vitro Model for Regenerative Endodontic Procedures

Dental Hypotheses, 2023
Introduction: Dental pulp regeneration is fundamental in dentistry and endodontics; however, few in vitro experimental models are available to study its biological process.
Saber Khazaei, Rezvan Amirkhani, Azam Bozorgi, Mozafar Khazaei   +3 more
doaj   +1 more source

The roles of endoglin gene in cerebrovascular diseases. [PDF]

, 2017
Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis.
Ma, Li, Su, Hua, Zhang, Rui, Zhu, Wan
core   +2 more sources

Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture

Cell Communication and Signaling, 2010
Background Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma-
Robboy Stanley J, Walmer David K, Kissling Grace E, Castro Lysandra, Wang Lu, Swartz Carol D, Zheng Xaiolin, Yu Linda, Moore Alicia B, Dixon Darlene   +9 more
doaj   +1 more source

Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist. [PDF]

PLoS ONE, 2010
Transforming growth factor-beta (TGFbeta) homologues form a diverse superfamily that arose early in animal evolution and control cellular function through membrane-spanning, conserved serine-threonine kinases (RII and RI receptors).
Jie Zhu, Edward L Braun, Satomi Kohno, Monica Antenos, Eugene Y Xu, Robert W Cook, S Jack Lin, Brandon C Moore, Louis J Guillette, Theodore S Jardetzky, Teresa K Woodruff   +10 more
doaj   +1 more source

The pituitary TGFb1 system as a novel target for the treatment of resistant prolactinomas [PDF]

, 2016
Prolactinomas are the most frequently observed pituitary adenomas and most of themrespond well to conventional treatment with dopamine agonists (DAs).
Camilletti, María Andrea, Diaz, Graciela Susana, Recouvreux, Maria Victoria, Rifkin, Daniel B.   +3 more
core   +2 more sources

TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study

BMC Cancer, 2007
Background Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter.
Guo Qun, Penney Kathryn, Cox David G, Hankinson Susan E, Hunter David J   +4 more
doaj   +1 more source