Results 111 to 120 of about 738,282 (345)

Obesity and cancer: existing and new hypotheses for a causal connection [PDF]

, 2018
Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail, McPherson, Megan, Stone, Trevor W.   +2 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Severe invasive infections linked to IRAK2 immune variants

International Journal of Infectious Diseases
In subjects with peculiar susceptibility to severe infections by common pyogenic bacteria, mutations of interleukin-1 receptor-associated kinase proteins (IRAK)1 and IRAK4 had been identified.
Aseervatham Anusha Amali, Kathirvel Paramasivam, Sharada Ravikumar, Zhaohong Tan, Shaun Seh Ern Loong, Kelvin Han Chung Chong, Alicia Ang, Jin Zhu, Suma Sathyanarayana Rao, Louis Yi Ann Chai   +9 more
doaj   +1 more source

Structure of TRAF Family: Current Understanding of Receptor Recognition

Frontiers in Immunology, 2018
Tumor necrosis factor receptor–associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis.
Hyun H. Park
doaj   +1 more source

Cell death and life in cancer: mathematical modeling of cell fate decisions

, 2011
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells.
Barillot, Emmanuel, Calzone, Laurence, Fourquet, Simon, Tournier, Laurent, Zinovyev, Andrei   +4 more
core   +2 more sources

Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]

, 2016
Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht, Changjun Yin, Christian Weber, Coleen A. McNamara, Desheng Hu, Gianluca Grassia, Kulkarni U, Li Peng, Michael Beer, Pasquale Maffia, Prasad Srikakulapu, Rudolf A. Manz, Sai Vineela Bontha, Sarajo K. Mohanta   +13 more
core   +1 more source

Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors

Journal of Experimental Medicine, 1990
The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human ...
M. Shalaby, A. Sundan, H. Loetscher, M. Brockhaus, W. Lesslauer, T. Espevik   +5 more
semanticscholar   +1 more source

Targeting tumor necrosis factor receptors in ankylosing spondylitis

Annals of the New York Academy of Sciences, 2018
AbstractOver the past two decades, considerable advances in our understanding of inflammatory and immune pathways have allowed for the growing use of targeted biologic therapy. Most notably, the introduction of tumor necrosis factor (TNF) inhibitors has dramatically changed the management of autoimmune inflammatory disorders, including ankylosing ...
Michal, Lata, Aubryanna S, Hettinghouse, Chuan-Ju, Liu   +2 more
openaire   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Plasma levels of immunoinflammatory markers in De Novo coronary atherosclerosis and coronary restenosis postangioplasty

Arquivos Brasileiros de Cardiologia, 2001
OBJECTIVE: To compare circulating plasma levels of immunoinflammatory markers in patients with known de novo coronary artery disease and patients with postangioplasty restenosis.
Alexandre Schaan de Quadros, Jorge Pinto Ribeiro, Waldomiro Carlos Manfroi, Cristiane Leitão, Karen Ordovás, Letícia Weiss, Nadine Clausell   +6 more
doaj   +1 more source