Results 41 to 50 of about 5,796,978 (304)

Circulating tumor necrosis factor receptors are associated with mortality and disease severity in COVID-19 patients.

PLoS ONE, 2022
BackgroundAlthough hyperinflammatory response influences the severity of coronavirus disease 2019 (COVID-19), little has been reported about the utility of tumor necrosis factor (TNF)-related biomarkers in reflecting the prognosis.
Tomohito Gohda, Maki Murakoshi, Yusuke Suzuki, Makoto Hiki, Toshio Naito, Kazuhisa Takahashi, Yoko Tabe   +6 more
doaj   +2 more sources

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α [PDF]

, 2013
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B ...
Unlu, Sebnem, Gillian M. Tannahill (440532), O’Neill Luke A., Kent Z. Q. Wang (440530), Kent Z. Q. Wang, Galson, Deborah L., Galson Deborah L., Luke A. O’Neill (440534), Tannahill Gillian M., Auron Philip E., O'Neill, LA, Adamik, Juraj, Su An-Jey A., Gillian M. Tannahill, Sebnem Unlu, Philip E. Auron, Unlu Sebnem, Gillian M Tannahill, Adamik, J, An-Jey A. Su, Yan, Chunhong, Auron, PE, Deborah L. Galson, Luke A. O’Neill, Luke A O'Neill, O’Neill, Luke A., Su, AJA, Tannahill, GM, An-Jey A. Su (440531), O\u27Neill, Luke A., Deborah L Galson, Wang, KZQ, An-Jey A Su, Kent Z Q Wang, Unlu, S, Sebnem Unlu (156119), Wang, Kent Z. Q., Juraj Adamik (440529), Galson, DL, Adamik Juraj, Philip E. Auron (440535), Philip E Auron, Wang Kent Z. Q., Su, An Jey A., Tannahill, Gillian M., Su, An-Jey A., Wang, Kent Z.Q., Deborah L. Galson (440533), Auron, Philip E., Juraj Adamik   +49 more
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Cytokines and troponin-I in cardiac dysfunction after coronary artery grafting with cardiopulmonary bypass

Arquivos Brasileiros de Cardiologia, 2001
OBJECTIVE: The association between cytokines and troponin-I with cardiac function after cardiac surgery with cardiopulmonary bypass remains a topic of continued investigation.
Neverton Savaris, Carisi Polanczyk, Nadine Clausell   +2 more
doaj   +1 more source

TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro. [PDF]

PLoS ONE, 2011
Signaling by Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and Fas ligand (FasL) has been proposed to contribute to the chemosensitivity of tumor cells treated with various other anti-cancer agents.
Christina Menke, Tatiana Goncharov, Lubna Qamar, Christopher Korch, Heide L Ford, Kian Behbakht, Andrew Thorburn   +6 more
doaj   +1 more source

Macrophages as a source of tumoricidal activity (tumor-necrotizing factor) [PDF]

, 1980
Macrophage-enriched peritoneal exudate cells from mice infected with Mycobacterium bovis BCG, macrophage-like tumor cells (PU 5-1.8), and peritoneal macrophages propagated in vitro with macrophage growth factor released tumoricidal activity into the ...
Mannel, D N, Moore, R. N., Männel, D. N., Mergenhagen, S E, Mergenhagen, S. E., Moore, R N   +5 more
core   +1 more source

Relationship between Dynamics of TNF-α and Its Soluble Receptors in Saliva and Periodontal Health State

Dentistry Journal, 2022
Soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) are reported to protect against excessive TNF-α, a primary mediator of systemic responses to infection.
Ryota Kibune, Kosuke Muraoka, Masaki Morishita, Wataru Ariyoshi, Shuji Awano   +4 more
doaj   +1 more source

The rs11684747 and rs55790676 SNPs of ADAM17 influence tuberculosis susceptibility and plasma levels of TNF, TNFR1, and TNFR2

Frontiers in Microbiology
IntroductionThe proteolytic activity of A Disintegrin and Metalloproteinase 17 (ADAM17) regulates the release of tumor necrosis factor (TNF) and TNF receptors (TNFRs) from cell surfaces.
José Alberto Choreño-Parra, José Alberto Choreño-Parra, Lucero A. Ramon-Luing, Manuel Castillejos, Emmanuel Ortega-Martínez, Emmanuel Ortega-Martínez, Emmanuel Ortega-Martínez, Alan Rodrigo Tapia-García, Alan Rodrigo Tapia-García, Melvin Barish Matías-Martínez, Melvin Barish Matías-Martínez, Alfredo Cruz-Lagunas, Gustavo Ramírez-Martínez, Itzel Alejandra Gómez-García, Itzel Alejandra Gómez-García, Jazmín Ariadna Ramírez-Noyola, Jazmín Ariadna Ramírez-Noyola, Beatriz Garcia-Padrón, Beatriz Garcia-Padrón, Karen Gabriel López-Salinas, Karen Gabriel López-Salinas, Fabiola Jiménez-Juárez, Fabiola Jiménez-Juárez, Parménides Guadarrama-Ortiz, Citlaltepetl Salinas-Lara, Citlaltepetl Salinas-Lara, Karolina Bozena-Piekarska, Marcela Muñóz-Torrico, Leslie Chávez-Galán, Joaquín Zúñiga, Joaquín Zúñiga   +30 more
doaj   +1 more source

Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL

Analytical Cellular Pathology, 2010
Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1)
Bodvael Pennarun, Jan H. Kleibeuker, Tjitske Oenema, Janet H. Stegehuis, Elisabeth G.E. de Vries, Steven de Jong   +5 more
doaj   +1 more source

Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction

Communications Biology, 2022
Yang et al report that intrinsic cardiac adrenergic cell-derived norepinephrine promotes myocardial dysfunction in response to LPS. They demonstrate norepinephrine produced by these cells activated β1-adrenergic receptors on cardiomyocytes increasing the
Duomeng Yang, Xiaomeng Dai, Yun Xing, Xiangxu Tang, Guang Yang, Andrew G. Harrison, Jason Cahoon, Hongmei Li, Xiuxiu Lv, Xiaohui Yu, Penghua Wang, Huadong Wang   +11 more
doaj   +1 more source

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]

, 2005
Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Taylor, DL, Pocock, JM, Jones, F, Kubota, ESFCS   +3 more
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