Results 91 to 100 of about 666,578 (361)
Angiogenic Factors produced by Hypoxic Cells are a leading driver of Anastomoses in Sprouting Angiogenesis---a computational study [PDF]
Scientific Reports volume 8, Article number: 8726 (2018), 2018 Angiogenesis - the growth of new blood vessels from a pre-existing vasculature - is key in both physiological processes and on several pathological scenarios such as cancer progression or diabetic retinopathy. For the new vascular networks to be functional, it is required that the growing sprouts merge either with an existing functional mature vessel ...
arxiv +1 more source
Molecular and cellular responses of normal human trophoblast to vascular endothelial growth factor and placenta growth factor [PDF]
, 1999 Implantation and growth of the placenta requires extensive angiogenesis in fetal villi and maternal decidua to form vascular structures involved in placental exchange.
Desai, Jayashree
core +1 more source
Journal of Neuropathology and Experimental Neurology, 1998 Vascular endothelial growth factor (VEGH) is a known endothelial mitogen and a potent enhancer of vascular permeability although its role in focal cerebral ischemia is still not completely understood.
F. Lennmyr +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
VEGFR1-tyrosine kinase signaling in pulmonary fibrosis
Inflammation and Regeneration, 2021 Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano +4 more
doaj +1 more source
Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins [PDF]
, 2012 The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses ...
Alitalo, Kari Kustaa, Jeltsch, Michael
core
Identification of functional VEGF receptors on human platelets [PDF]
, 2002 Platelets secrete platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) upon stimulation. We have demonstrated that platelets have functionally active PDGF α-receptors, a transmembrane tyrosine kinase involved in negative ...
Holmsen, Holm +2 more
core +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Journal of Translational Medicine, 2012 Background Dovitinib is a receptor tyrosine kinase (RTK) inhibitor targeting vascular endothelial growth factor receptors, fibroblast growth factor receptors and platelet-derived growth factor receptor β. Dovitinib is currently in clinical trials for the
Chen Zhi-Yuan +9 more
doaj +1 more source
Stevens-Johnson Syndrome Induced by Vandetanib [PDF]
, 2011 Vandetanib is a once-daily oral anticancer drug that selectively inhibits key signaling pathways in cancer by targeting vascular endothelial growth factor receptors, epidermal growth factor receptors tyrosine kinase, and rearranged during transfection ...
Annunziata +9 more
core +2 more sources