Results 11 to 20 of about 491,094 (347)

Signal transduction by vascular endothelial growth factor receptors. [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this family of five mammalian ligands, which act through three receptor tyrosine kinases (RTKs).
S. Koch, L. Claesson-Welsh
semanticscholar   +3 more sources

Signal transduction by vascular endothelial growth factor receptors.

Biochemical Society Transactions, 2001
Vascular endothelial growth factor (VEGF)/vascular permeability factor is the prototype for a growing family of dimeric growth factors, which exert their effects on vascular and lymphatic endothelial cells, as well as on a wide range of other cell types.
L. Claesson-Welsh
semanticscholar   +3 more sources

Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke. [PDF]

PLoS ONE, 2011
We identified that the angiotensin receptor antagonist, candesartan, has profound neurovascular protective properties when administered after ischemic stroke and was associated with a proangiogenic state at least partly explained by vascular endothelial ...
Weihua Guan, Payaningal R Somanath, Anna Kozak, Anna Goc, Azza B El-Remessy, Adviye Ergul, Maribeth H Johnson, Ahmed Alhusban, Sahar Soliman, Susan C Fagan   +9 more
doaj   +1 more source

Extrahepatic Angiogenesis: A Potential Common Pathophysiological Basis of Multiple Organ Dysfunction in Rats with Cholestasis Cirrhosis

Frontiers in Bioscience-Landmark, 2023
Background: In addition to intrahepatic angiogenesis, patients with cholestasis cirrhosis develop extrahepatic vasculature disorders and functional disturbances of multiple organ systems.
Dandan Wang, Chunyong Yang, Ziyang Zeng, Xianfeng Wu, Hao Liang, Xiaoyan Hu, Yizhu Sun, Junhong Li, Jun Li, Xin Shu, Zhiyong Yang, Xiaobo Wang, Karine Belguise, Yujie Li, Bin Yi   +14 more
doaj   +1 more source

Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats

Clinics, 2011
INTRODUCTION: Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide ...
Majid Khazaei, Ali Reza Fallahzadeh, Mohammad Reza Sharifi, Noushin Afsharmoghaddam, Shaghayegh Haghjooy Javanmard, Ensieh Salehi   +5 more
doaj   +1 more source

Efficacy and safety of nintedanib in patients with non-small cell lung cancer, and novel insights in radiation-induced lung toxicity

Frontiers in Oncology, 2023
Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan, Shuyu Xue, Tiantian Wang, Ruihang Gao, Hanqiao Zeng, Qianmeng Wang, Xiaojing Jia   +6 more
doaj   +1 more source

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]

, 2013
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen, A Kim, A Tuuttila, Ahmed H. Mujamammi, B AnandApte, C Alam, C Fischer, CA Bootle-Wilbraham, CA Staton, Claire E. Lewis, D Matei, DR Robinson, DW Seo, F Kazazi-Hyseni, FX Gomis-Ruth, G Bergers, G Fassina, G Fuh, H Gitay-Goren, HB Patel, J Mintseris, J Waltenberger, JC Tille, JE Rundhaug, JH Qi, JH Qi, JR Jackson, JR Worley, K Maskos, KP Langton, KP Langton, LA Kelley, M Bandt De, M Benedetto Di, M Lohela, M Wisniewska, Michael D. Barker, Michael P. Seed, MS Brozzo, Munitta Muthana, N Manabe, Nicola J. Brown, Q Ebrahem, Rita Jones, S Rosengren, S Sivaprasad, SE Hoegy, V Chabottaux, WH Yu, WU Kim, Y Cao, Y Matsumoto, Yung-Yi Chen   +52 more
core   +1 more source

VEGF: An essential mediator of both angiogenesis and endochondral ossification [PDF]

, 2007
During bone growth, development, and remodeling, angiogenesis as well as osteogenesis are closely associated processes, sharing some essential mediators.
Dai, J, Rabie, ABM
core   +1 more source

Recent advances in ocular drug delivery systems and targeting VEGF receptors for management of ocular angiogenesis: A comprehensive review

Future Journal of Pharmaceutical Sciences, 2021
Background Angiogenic ocular diseases address the main source of vision impairment or irreversible vision loss. The angiogenesis process depends on the balance between the pro-angiogenic and anti-angiogenic factors.
Soumya Narayana, Mohammed Gulzar Ahmed, B. H. Jaswanth Gowda, Pallavi K. Shetty, Arfa Nasrine, M. Thriveni, Nadira Noushida, A. Sanjana   +7 more
doaj   +1 more source

Aktuelle Entwicklungen und Perspektiven zielgerichteter Therapien [PDF]

, 2010
Current Developments and Perspectives in Targeted Therapies Many different approaches for improving the prognosis of patients with advanced non-small-cell lung cancer (NSCLC) are currently being investigated.
Dickgreber, Nicolas, Huber, Rudolf M., Reck, Martin, Reinmuth, Niels, Schütte, Wolfgang, Serke, Monika, Wolf, Jürgen   +6 more
core   +1 more source