Results 51 to 60 of about 666,578 (361)
Journal of Biological Chemistry, 1996 Vascular endothelial growth factor (VEGF), a potent angiogenic factor, uses two receptor tyrosine kinases, FLK/KDR and FLT, to mediate its activities. We have cross-linked I-VEGF to the cell surface of various tumor cell lines and of human umbilical vein
S. Soker +3 more
semanticscholar +1 more source
Heliyon, 2023 Background: Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play complicated oncogenic roles in multiple tumors by initiating and promoting tumor angiogenesis and lymphangiogenesis.
Jianxin Li, Ting Han
doaj
Бюллетень сибирской медицины, 2016 The literature review focuses on the role of various growth factors in the developing vasculature of the ovary. Vascularization plays an important role in physiological processes such as development and atresia of a follicle, the formation of the yellow ...
V. G. Zenkina
doaj +1 more source
Animals, 2021 The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and their receptors—FGFR1 ...
Pedro Pinto-Bravo +10 more
doaj +1 more source
Vascular endothelial growth factor signaling in development and disease
Development, 2018 Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems.
Sinem Karaman, V. Leppänen, K. Alitalo
semanticscholar +1 more source
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from G{alpha}12/13 and G{alpha}11/q [PDF]
The Journal of Biological Chemistry 283, 44 (2008) 29888-96, 2008 Increase in vascular permeability occurs under many physiological conditions and is central in diverse human pathologies. Thrombin is a pro-coagulant serine protease, which causes the local loss of endothelial barrier integrity thereby enabling the rapid extravasation of plasma proteins and the local formation of fibrin-containing clots.
arxiv +1 more source
Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A [PDF]
International Journal of Breast Cancer, 2013 VEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression, lymph node status, tumour size, histological grade, and hormone receptor status.
Nahida Srabovic +6 more
openaire +3 more sources
Journal of Translational Medicine, 2022 Background An imbalance in the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) during pregnancy plays an important role in the pathogenesis of gestational diabetes mellitus (GDM) and eclampsia.
Alayi Bolatai, Yujing He, Na Wu
doaj +1 more source
Reducing Placental Oxidative Stress in a Rat Model Preeclampsia Using VEGFR2 Nanoparticles [PDF]
, 2023 Preeclampsia is a complication of pregnancy, where the placenta lacks sufficient blood flow due to abnormal formation of the vascular endothelial cells. This results in hypertension and increased reactive oxygen species, causing oxidative stress.
Ganios, Sophia
core +1 more source
Circulation Research, 2004 Systemic sclerosis (SSc) skin lesions are characterized by disturbed vessel morphology with enlarged capillaries and an overall reduction in capillary density, suggesting a deregulated, insufficient angiogenic response.
O. Distler +12 more
semanticscholar +1 more source