Results 51 to 60 of about 201,272 (268)

VEGFR1-tyrosine kinase signaling in pulmonary fibrosis

Inflammation and Regeneration, 2021
Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono, Yoshiya Ito   +4 more
doaj   +1 more source

Cheiradone: a vascular endothelial cell growth factor receptor antagonist [PDF]

BMC Cell Biology, 2008
Abstract Background Angiogenesis, the growth of new blood vessels from the pre-existing vasculature is associated with physiological (for example wound healing) and pathological conditions (tumour development). Vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2) and epidermal growth factor ...
Sajjad Hussain, Mark Slevin, M. Ahmed Mesaik, M. Iqbal Choudhary, Abdul H Elosta, Sabine Matou, Nessar Ahmed, David C. West, John Gaffney   +8 more
openaire   +5 more sources

Vascular Endothelial Growth Factor Ligands and Receptors in Breast Cancer

Journal of Clinical Medicine, 2023
Breast cancer (BC) is the most common malignancy responsible for the largest number of deaths in women worldwide. The risk of developing BC is predisposed by many factors such as age, presence of genetic mutations or body weight. The diagnosis is mostly made relatively late, which is why patients are exposed to radical surgical treatments, long-term ...
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko   +2 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

DIAGNOSTIC SIGNIFICANCE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH PRIMARY MITRAL VALVE PROLAPSE

Кардиоваскулярная терапия и профилактика, 2017
Aim. To evaluate diagnostic significance of the type A vascular endothelial growth factor (VEGF-A) and its receptors type 1 and 2 (VEGF-R1 and VEGF-R2) in primary mitral valve prolapse (MVP) patients.Material and methods. Totally, 83 MVP patients studied:
A. V. Yagoda, N. N. Gladkikh, Т. E. Zangelova   +2 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors [PDF]

The Journal of Cell Biology, 2007
Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow–derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and ...
Ball, Stephen G., Shuttleworth, C. Adrian, Kielty, Cay M.   +2 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Effect of Vascular Endothelial Growth Factor Antagonist Peptide (VGB4) on Breast Tumor Growth Suppression in Vivo

Armaghane Danesh Bimonthly Journal, 2019
Background & aim: The vascular endothelial growth factor of the tumor, which binds to its receptors at the level of endothelial cells, plays an important role in vascular permeability and tumor angiogenesis.
M Farzaneh Behelgardi, S Zahri, F Mashayekhi, SM Asghari   +3 more
doaj  

Monitoring Dual VEGF Inhibition in Human Pancreatic Tumor Xenografts With Dynamic Contrast-Enhanced Ultrasound

Technology in Cancer Research & Treatment, 2020
Background: Association of drugs acting against different antiangiogenic mechanisms may increase therapeutic effect and reduce resistance. Noninvasive monitoring of changes in the antiangiogenic response of individual tumors could guide selection and ...
Michele Lamuraglia MD, PhD, Guillaume Barrois PhD, Delphine Le Guillou-Buffello PhD, Mathieu Santin PhD, Anne Kerbol MD, Eva Comperat MD, Alain Coron PhD, Olivier Lucidarme MD, PhD, S. Lori Bridal PhD   +8 more
doaj   +1 more source