Results 81 to 90 of about 666,578 (361)

LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure

Cell Death and Disease, 2021
Transforming growth factor beta (TGFβ) signalling regulates extracellular matrix accumulation known to be essential for the pathogenesis of renal fibrosis; latent transforming growth factor beta binding protein 4 (LTBP4) is an important regulator of TGFβ
Chi-Ting Su, Tzu-Ming Jao, Zsolt Urban, Yue-Jhu Huang, Daniel H. W. See, Yao-Chou Tsai, Wei-Chou Lin, Jenq-Wen Huang   +7 more
doaj   +1 more source

Exploring the Intracrine Functions of VEGF-A

Biomolecules, 2021
Vascular endothelial growth factor A (VEGF-A or VEGF) is a highly conserved secreted signalling protein best known for its roles in vascular development and angiogenesis.
Sophie Wiszniak, Quenten Schwarz
doaj   +1 more source

Transcriptional profiling reveals fundamental differences in iPS-derived progenitors of endothelial cells (PECs) versus adult circulating EPCs [PDF]

arXiv, 2020
There are a number of different stem cell sources that have the potential to be used as therapeutics in vascular degenerative diseases. On the one hand, there are so called endothelial progenitor cells (EPCs), which are typically derived from adult blood. They carry the marker CD34, but the true nature and definition of EPCs is still controversial.
arxiv  

Immunolocalization of angiogenic growth factors in the ovine uterus during the oestrus cycle and in response to Steroids [PDF]

, 2018
The vascular changes associated with endometrial maturation in preparation for embryo implantation depend on numerous growth factors, known to regulate key angiogenic events.
Boroujeni, Bridges, Charnock-Jones, Coffelt, Cullinan-Bove, Das, Fan, Gabler, Girling, Grazul-Bilska, Guo, Guo, Heryanto, Hirchenhain, Johnson, Kappou, Kazi, Kazi, Lash, Ma, Maas, Matsumoto, Meduri, Moller, Mueller, Nayak, Nayak, Niklaus, Ponglowhapan, Punyadeera, Raheem, Robinson, Rowe, Ruiz-Gonzalez, Sagsoz, Sagsoz, Shweiki, Tasaki, Thomas, Torry, Tsuzuki, Walter, Winther, Woolf   +43 more
core   +1 more source

AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts.

Cancer Research, 2006
The growth of solid tumors is dependent on the continued stimulation of endothelial cell proliferation and migration resulting in angiogenesis. The angiogenic process is controlled by a variety of factors of which the vascular endothelial growth factor ...
A. Polverino, A. Coxon, C. Starnes, Zobedia Diaz, T. DeMelfi, Ling Wang, J. Bready, Juan Estrada, R. Cattley, S. Kaufman, Danlin Chen, Yongmei Gan, Gondi N. Kumar, James T. Meyer, Sesha Neervannan, Gonzalo Alva, J. Talvenheimo, S. Montestruque, A. Tasker, V. Patel, R. Radinsky, R. Kendall   +21 more
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions.

The Oncologist, 2006
Angiogenesis plays a central role in the process of tumor growth and metastatic dissemination. The vascular endothelial growth factor (VEGF) family of peptide growth factors and receptors are key regulators of this process. Agents directed either against
A. Morabito, E. De Maio, M. Di Maio, N. Normanno, F. Perrone   +4 more
semanticscholar   +1 more source

Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes [PDF]

Blood, 1993
Abstract Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) is a polypeptide mediator, elaborated by certain tumors and other cell types, that exerts multiple effects on endothelium via interaction with a class of high-affinity binding sites.
J Ryan, D. T. Connolly, J Kao, P Tijburg, David M. Stern, H Shen, L Borden, Ann Marie Schmidt, Matthias Clauss   +8 more
openaire   +4 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

DIAGNOSTIC SIGNIFICANCE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH PRIMARY MITRAL VALVE PROLAPSE

Кардиоваскулярная терапия и профилактика, 2017
Aim. To evaluate diagnostic significance of the type A vascular endothelial growth factor (VEGF-A) and its receptors type 1 and 2 (VEGF-R1 and VEGF-R2) in primary mitral valve prolapse (MVP) patients.Material and methods. Totally, 83 MVP patients studied:
A. V. Yagoda, N. N. Gladkikh, Т. E. Zangelova   +2 more
doaj   +1 more source