Results 1 to 10 of about 50,162 (238)
Vasopressin receptor antagonists [PDF]
Kidney International, 2006 The first non-peptide vasopressin receptor antagonist (VRA) was recently approved by the United States Food and Drug Administration, and several others are now in late stages of clinical development. Phase 3 trials indicate that these agents predictably reduce urine osmolality, increase electrolyte-free water excretion, and raise serum sodium ...
Arthur Greenberg, Joseph G. Verbalis
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Phosphorylation of the V2 Vasopressin Receptor [PDF]
Journal of Biological Chemistry, 1997 The V2 vasopressin receptor undergoes ligand-induced sequestration and desensitization (Birnbaumer, M., Antaramian, A., Themmen, A. P. N., and Gilbert, S. (1992) J. Biol. Chem. 267, 11783-11788). The V2 receptor expressed in transfected cells labeled with [32P] orthophosphate was phosphorylated following the addition of 100 nM arginine vasopressin (AVP)
INNAMORATI, Giulio +3 more
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Vasopressin and Vasopressin Receptor Antagonists [PDF]
Electrolyte & Blood Pressure, 2008 Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V1a, V1b, and V2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V2 receptors in the kidney.
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Vasopressin V2 receptor antagonists [PDF]
Cardiovascular Research, 2001 Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and disorders of water retention such as congestive heart failure and cirrhosis is a common problem encountered in the care of the medical patient. Thus far, available treatment modalities for disorders of excess arginine vasopressin (AVP) secretion or action have ...
Joseph G. Verbalis, Lisa L. Wong
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Vasopressin Receptor Expression in the Placenta [PDF]
Biology of Reproduction, 2003 The arginine vasopressin (AVP) type 1a receptor (V1a) is well known to mediate vasoconstriction. In pregnancy, blood flow in the placenta is crucial for sustaining normal growth and development of the fetus. This is the first AVP receptor study in the placenta and fetal membranes. The aim was to compare, quantitatively, the level of V1a gene expression
Irene Koukoulas +7 more
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Vasopressin receptor-mediated endocytosis in cells transfected with V1-type vasopressin receptors
Kidney International, 1993 We examined the process of receptor-mediated endocytosis in A-9 lung fibroblast and chinese hamster ovary (CHO) cells transfected with the recently cloned vasopressin V1a receptor (51). We used a fluorescent labeled vasopressin analog (rhodamine-mercaptopropionic acid lysine vasopressin) and radiolabeled vasopressin to examine this process in the two ...
Lutz, W +5 more
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Hyponatremia, Arginine Vasopressin Dysregulation, and Vasopressin Receptor Antagonism [PDF]
American Journal of Nephrology, 2006 Hyponatremia is often associated with arginine vasopressin (AVP) dysregulation that is regulated by the hypothalamo-neurohypophyseal tract in response to changes in plasma osmolality, commonly in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Amit Rai +3 more
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Transient Phosphorylation of the V1a Vasopressin Receptor [PDF]
Journal of Biological Chemistry, 1998 The V1a arginine vasopressin receptor (V1aR) expressed in HEK 293 cells was phosphorylated after binding to arginine vasopressin (AVP). The phosphate was incorporated very rapidly into the protein but remained attached for a very short time despite the continuous presence of hormone.
INNAMORATI, Giulio +2 more
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Vasopressin receptors V1aand V2 are not osmosensors [PDF]
Physiological Reports, 2015 Herein, we investigated whether G protein-coupled signaling via the vasopressin receptors of the V1a and V2 subtypes (V1aR and V2R) could be obtained as a direct response to hyperosmolar challenges and/or whether hyperosmolar challenges could augment classical vasopressin-dependent V1aR signaling.
Pedersen, Kasper Lykke +4 more
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Vasopressin V2 receptor antagonists [PDF]
Journal of Molecular Endocrinology, 2002 Hyponatremia, whether due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or disorders of water retention such as congestive heart failure and cirrhosis, is a very common problem encountered in the care of medical patients. To date, available treatment modalities for disorders of excess arginine vasopressin (AVP) secretion or ...
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