Results 101 to 110 of about 50,162 (238)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Endoplasmic reticulum (ER) stress is a crucial pathogenic mechanism in alcoholic liver disease (ALD). B‐cell receptor‐associated protein 31 (BAP31) can regulate ER homeostasis and anti‐apoptosis, but the function and regulation of BAP31 in ALD are unclear.
Sai Wang, Yufeng Wang, Wen Shan, Guoyang Li, Ran Yan, Zhecheng Wang, Yan Zhao, Jihong Yao, Ning Zhang   +8 more
wiley   +1 more source

Advancing antihypertensive drug development

British Journal of Pharmacology, EarlyView.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

British Journal of Pharmacology, EarlyView.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio, Luiz G. S. Branco, Fernanda Brognara, Patrícia Passaglia, Roberta Foresti, Roberto Motterlini   +5 more
wiley   +1 more source

The DCIDE framework: systematic investigation of evolutionary hypotheses, exemplified with autism

Biological Reviews, EarlyView.
ABSTRACT Evolutionary explanations of mental disorders are a longstanding aim of evolutionary psychiatry, but have suffered from complexities including within‐disorder heterogeneity and environmental effects of contemporary societies obscuring possible ancestral functions.
Adam D. Hunt, Adrian V. Jaeggi
wiley   +1 more source

Clinical Presentation of Congenital Hypopituitarism: Lessons From a Large Academic Centre

Clinical Endocrinology, Volume 102, Issue 6, Page 649-655, June 2025.
ABSTRACT Objective Pituitary hormone deficiencies are associated with considerable morbidity, yet the variability of presentation and evolution of congenital hypopituitarism remains unexplored. This study investigated differences in presentation of congenital isolated pituitary hormone deficiency (cIPHD) versus congenital multiple pituitary hormone ...
Jennifer M. Ladd, Amy L. Pyle‐Eilola, Leena Mamilly, Monika Chaudhari, Rohan K. Henry   +4 more
wiley   +1 more source

Vasopressin Receptor Antagonists. Therapeutic Efficacy of Vasopressin Receptor Antagonists.

Internal Medicine, 1998
Toshikazu Saito, San-e Ishikawa
openaire   +3 more sources

Patient Participation in Urine Specific Gravity Screening for Arginine Vasopressin Deficiency in an Inpatient Neurosurgical Clinic

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Detecting hypotonic urine (specific gravity < 1005 g/L) is crucial for the early identification of arginine vasopressin deficiency (AVP‐deficiency), a common complication after pituitary surgery. This study aimed to evaluate the agreement between urine specific gravity measurements taken by patients using urine test strips and those ...
Jeanne‐Marie Nollen, Anja H. Brunsveld‐Reinders, Nienke R. Biermasz, Marco J. T. Verstegen, Eline Leijtens, Wilco C. Peul, Ewout W. Steyerberg, Wouter R. van Furth   +7 more
wiley   +1 more source

Vasopressin: a review of clinical indications. [PDF]

Clin Exp Emerg Med
Oliva G, Ulloa N.
europepmc   +1 more source

Navigating the Australian child protection system: The importance of formal and informal support for carers to effectively provide care to children in out‐of‐home care

Child &Family Social Work, Volume 30, Issue 2, Page 237-250, May 2025.
Abstract Children in out‐of‐home care (OOHC) are a vulnerable group who often experience poorer outcomes than their peers who are not in OOHC. In 2020–2021, there were approximately 46 200 children in OOHC in Australia, with 91% in a family setting with foster or kinship carers. Data from other countries show similar patterns indicating that foster and
Jemma Venables, Jenny Povey, Madonna Boman, Karen Healy, Janeen Baxter, Sophie Austerberry, Kate Thompson   +6 more
wiley   +1 more source