Results 121 to 130 of about 27,910 (308)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Vasopressin and oxytocin receptors in GtoPdb v.2025.3

Vasopressin (AVP) and oxytocin (OT) receptors (nomenclature as recommended by NC-IUPHAR [98]) are activated by the endogenous cyclic nonapeptides vasopressin and oxytocin.
Guillon, Gilles, Serradeil-Le Gal, Claudine, Manning, Maurice, Gruber, Christian, Busnelli, Marta, Knepper, Mark, Kimura, Tadashi, Lolait, Stephen, Bouvier, Michel, O\u27Carroll, Anne-Marie, Chini, Bice, Soloff, Melvyn, Wheatley, Mark, Gimpl, Gerald, Zingg, Hans H., Bichet, Daniel, Mouillac, Bernard, Verbalis, Joseph G.   +17 more
core   +1 more source

Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology

Clinical Endocrinology, EarlyView.
ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth, Thomas J. O'Leary, Craig L. Doig, Natalie Taylor, Jasminder Dosanjh, David R. Woods, Michael J. Stacey, Robert M. Gifford   +7 more
wiley   +1 more source

Genetic Insights Into AVP Deficiency: Identification of a Novel AVP Variant and Compilation of a Curated Catalogue of Pathogenic Variants

Clinical Genetics, EarlyView.
We identified a novel pathogenic AVP variant in two Danish families with autosomal dominant inheritance of symptoms of AVP deficiency. In addition, we compiled a catalogue of additionally 109 AVP variants that cause AVP deficiency and demonstrated the advantage of combining expert‐assisted curation, literature search, and online repositories to ensure ...
Jennifa Joseph, Esben Søndergaard, Sine Knorr, Jane Hagelskjær Knudsen, Søren Rittig, Jane Hvarregaard Christensen   +5 more
wiley   +1 more source

Structure and function of sea urchin neuropeptides

, 2010
PhDThe subject of this thesis is the identification and functional characterization of sea urchin neuropeptides. Neuropeptides are important mediators of neural signalling in all known animals with a nervous system, including bilaterians, ctenophorans ...
Rowe, Matthew Lyndon
core  

Electrophysiological and autoradiographical evidence of V1 vasopressin receptors in the lateral septum of the rat brain

, 1987
Extracellular recordings were obtained from single neurons located in the lateral septum, an area known to receive a vasopressinergic innervation in the rat brain.
Dreifuss, Jean-Jacques, Tribollet, Eliane, Raggenbass, Mario   +2 more
core   +1 more source

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, EarlyView.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Mapping the binding site of arginine vasopressin to V1a and V1b vasopressin receptors.

, 2007
International audienceStarting from the 2.8-A resolution x-ray structure of bovine rhodopsin, three-dimensional molecular models of the complexes between arginine vasopressin and two receptor subtypes (V1a, V1b) have been built.
Pena, Ana, Guillon, Gilles, Rognan, Didier, Durroux, Thierry, Murat, Brigitte, Trueba, Miguel, Rodrigo, Jordi   +6 more
core   +1 more source

Digital Dermatology

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Digital transformation is fundamentally reshaping dermatology, creating new opportunities in diagnostics, therapy, and healthcare organization. Large datasets combined with Artificial Intelligence (AI) enable more precise classification and prognosis, particularly through the analysis of clinical and dermoscopic imaging.
Lea Henkel, Avend Bamarni, Stephan Alexander Braun, Valentina Busik, Holger Andreas Haenssle, Stephan Rietz, Paul Schmidle, Sandra Schuh, Anna‐Theresa Seitz, Sebastian Sitaru, Stephan Traidl, Max Tischler, Felix von Krogh, Julia Welzel, Julia Winkler, Anastasia Sophie Vollmer, Katharina Susanne Kommoss, Alexander Zink   +17 more
wiley   +1 more source

Solubilization of ligand-stabilized vasopressin receptors from plasma membranes of bovine kidney and rat liver

, 1983
The solubilization of vasopressin receptors from plasma membranes of bovine kidney and rat liver by different detergents was investigated. A prerequisite for the extraction of vasopressin receptors retaining binding affinity for their ligand was the ...
Crause, P., Fahrenholz, F., Boer, R.
core   +1 more source