Results 121 to 130 of about 51,699 (307)

From prediction to intervention: Paradigm shifts in causal AI for precision medicine and large‐scale cohorts

VIEW, EarlyView.
Large‐scale cohorts and multimodal biomedical data have enabled powerful predictive models for clinical risk stratification, but prediction alone cannot guide effective interventions. This review introduces causal artificial intelligence as a design‐first framework that integrates target trial emulation, causal discovery, and robust effect estimation ...
Linlin Cao, Yudian Xu, Yifan Chen, Honghao Huang, Wei Xu, Jun Pu   +5 more
wiley   +1 more source

Approximate resolution convolution function for fitting a dispersion gap measured on a triple‐axis spectrometer

Journal of Applied Crystallography, EarlyView.
An analytical convoluted gap function is presented for fitting either a linear or a quadratic dispersion gap in a constant‐Q cut measured with a focused triple‐axis spectrometer. It outperforms previous methods of fitting a gap, without requiring a full resolution convolution.We present an analytical convoluted gap function for fitting dispersion gaps ...
Emma Y. Lenander, Silas B. Schack, Kim Lefmann, Henrik M. Rønnow   +3 more
wiley   +1 more source

The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies

Brazilian Journal of Medical and Biological Research, 2000
Recent studies from several groups have indicated that abnormal or ectopic expression and function of adrenal receptors for various hormones may regulate cortisol production in ACTH-independent hypercortisolism.
Lacroix A., N'Diaye N., Mircescu H., Tremblay J., Hamet P.   +4 more
doaj  

Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal

Cell Reports
Summary: Interoceptive signals dynamically interact with the environment to shape appropriate defensive behaviors. Hypothalamic hormones arginine-vasopressin (AVP) and oxytocin (OT) regulate physiological states, including water and electrolyte balance ...
Walter Francesconi, Valentina Olivera-Pasilio, Fulvia Berton, Susan L. Olson, Rachel Chudoba, Lorena M. Monroy, Quirin Krabichler, Valery Grinevich, Joanna Dabrowska   +8 more
doaj   +1 more source

Maternal glucocorticoids have persistent effects on offspring social phenotype irrespective of opportunity for social buffering

Journal of Animal Ecology, EarlyView.
This study tests whether early‐life maternal association buffers offspring from the effects of prenatal stress in a facultatively social lizard. Despite clear effects of maternal glucocorticoids on growth and social behaviour, social associations did not mitigate these effects, revealing limits to social buffering in this species.
Kirsty J. MacLeod, Alix Bouffet‐Halle, Erik Wapstra, Tobias Uller, Geoffrey M. While   +4 more
wiley   +1 more source

Vasopressin 1a Receptor Antagonists for Pathological Aggression in Neurodegenerative and Other CNS Diseases

Biomedicines
Background: Neurodegenerative diseases are a major health problem, and the neuropsychiatric symptoms seen in these diseases adversely impact the lives of patients, families, and caregivers. Inappropriate aggressive behavior is a highly disruptive symptom
Neal G. Simon, Michael J. Brownstein, Karen E. Anderson, Shi-fang Lu, Hilda T. Maibach   +4 more
doaj   +1 more source

Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe hepatic encephalopathy [PDF]

, 2004
There is increasing evidence that terlipressin is useful in patients with cirrhosis and hepatorenal syndrome, but there are no data of its use in patients with acute liver failure (ALF) in whom hepatorenal syndrome is common.
Davies, N.A., Hayes, P.C., Jalan, R., Lee, A., Mookerjee, R.P., Shawcross, D.L., Williams, R.   +6 more
core  

Loanwords and Linguistic Phylogenetics: *pelek̑u‐ ‘axe’ and *(H)a(i̯)g̑‐ ‘goat’1

Transactions of the Philological Society, Volume 123, Issue 1, Page 116-136, March 2025.
Abstract This paper assesses the role of borrowings in two different approaches to linguistic phylogenetics: Traditional qualitative analyses of lexemes, and quantitative computational analysis of cognacy. It problematises the assumption that loanwords can be excluded altogether from datasets of lexical cognacy.
Simon Poulsen
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Clinical Challenges in Transition to Adult Care for Young People With Endocrinopathies

Clinical Endocrinology, EarlyView.
ABSTRACT The complexity of transition of pediatric patients to adult care is well recognized, with a multidisciplinary approach widely agreed to be essential. Despite extensive existing literature in this area, practical guidance as to the management of specific medical aspects and how to address these with patients and families is lacking, with little
Margaret Zacharin, Quynh‐Nhu Nguyen
wiley   +1 more source