Results 101 to 110 of about 27,910 (308)

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, EarlyView.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Upregulation of V1a vasopressin receptors by glucocorticoids

, 2006
WRK1 cells (a rat mammary tumor cell line) exhibit a vasopressinergic receptor of V1a subtype tightly coupled to phospholipase C. Addition of dexamethasone to the culture medium principally potentiated the vasopressin-sensitive accumulation of inositol ...
M. N. Balestre, J. Ibarondo, P. Colson, A. Duvoid, G. Devilliers, G. Guillon   +5 more
core   +1 more source

Physical Anchoring‐Assisted Mechanically Guided Assembly for Material‐Independent 3D Mesostructures

Small, EarlyView.
Conventional mechanically guided 3D assembly relies on selective chemical bonding between 2D precursors and elastomeric substrates, imposing fundamental limitations on material compatibility and scalability. Here, we present a physically anchored, buckling‐guided assembly platform based on a rod array patterned elastomeric substrate (RPES).
Yeonhee Heo, Pei Liu, Jeongmin Yoo, Jae Hyuk Hwang, Gooyoon Chung, Dong‐Gyun Kim, Raudel Avila, Yoonseok Park   +7 more
wiley   +1 more source

Vasopressinergic modulation of stress responses in the central amygdala of the Roman high-avoidance and low-avoidance rat [PDF]

, 1992
The central nucleus of the amygdala (CEA) is selectively involved in the passive component of the behavioral (immobility) and the accompanying parasympathetic response during conditioned, stressful environmental challenges. Vasopressinergic mechanisms in
Driscoll, P.,, WIERSMA, A, Bohus, B., Roozendaal, B., Driscoll, P., Wiersma, A.,, Koolhaas, J.M., ROOZENDAAL, B, Bohus, B.,, DRISCOLL, P, Roozendaal, B.,, KOOLHAAS, JM, Koolhaas, J.M.,, Wiersma, A., BOHUS, B   +14 more
core   +1 more source

Vasoplegia treatments: the past, the present, and the future

Critical Care, 2018
Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic, cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving various mechanisms in vascular smooth muscle cells such as G protein-coupled
Bruno Levy, Caroline Fritz, Elsa Tahon, Audrey Jacquot, Thomas Auchet, Antoine Kimmoun   +5 more
doaj   +1 more source

From prediction to intervention: Paradigm shifts in causal AI for precision medicine and large‐scale cohorts

VIEW, EarlyView.
Large‐scale cohorts and multimodal biomedical data have enabled powerful predictive models for clinical risk stratification, but prediction alone cannot guide effective interventions. This review introduces causal artificial intelligence as a design‐first framework that integrates target trial emulation, causal discovery, and robust effect estimation ...
Linlin Cao, Yudian Xu, Yifan Chen, Honghao Huang, Wei Xu, Jun Pu   +5 more
wiley   +1 more source

Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia

Brain and Behavior, 2019
Objective This study investigates the expression of mRNA encoding vasopressin in the hypothalamus of autopsy brains of individuals diagnosed with schizophrenia.
Johannes R. Busch, Christina Jacobsen, Niels Lynnerup, Jytte Banner, Morten Møller   +4 more
doaj   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Upregulation of V1a vasopressin receptors by glucocorticoids

, 1992
WRK1 cells (a rat mammary tumor cell line) exhibit a vasopressinergic receptor of V1a subtype tightly coupled to phospholipase C. Addition of dexamethasone to the culture medium principally potentiated the vasopressin-sensitive accumulation of inositol ...
M. N. Balestre, J. Ibarondo, P. Colson, A. Duvoid, G. Devilliers, G. Guillon   +5 more
core   +1 more source

Maternal glucocorticoids have persistent effects on offspring social phenotype irrespective of opportunity for social buffering

Journal of Animal Ecology, EarlyView.
This study tests whether early‐life maternal association buffers offspring from the effects of prenatal stress in a facultatively social lizard. Despite clear effects of maternal glucocorticoids on growth and social behaviour, social associations did not mitigate these effects, revealing limits to social buffering in this species.
Kirsty J. MacLeod, Alix Bouffet‐Halle, Erik Wapstra, Tobias Uller, Geoffrey M. While   +4 more
wiley   +1 more source