Results 141 to 150 of about 2,349,142 (333)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies

Brazilian Journal of Medical and Biological Research, 2000
Recent studies from several groups have indicated that abnormal or ectopic expression and function of adrenal receptors for various hormones may regulate cortisol production in ACTH-independent hypercortisolism.
Lacroix A., N'Diaye N., Mircescu H., Tremblay J., Hamet P.   +4 more
doaj  

Gender-Specific Protection from Microvessel Rarefaction in Female Hypertensive Rats [PDF]

, 1998
Epidemiologic studies reveal that women have a significantly lower age-adjusted morbidity and mortality from cardiovascular disease than men, suggesting that gender is a cardiovascular disease risk factor.
Greene, Andrew S., Lombard, Julian H., Papanek, Paula E., Rieder, Mark J.   +3 more
core   +1 more source

SMART MRS: A Simulated MEGA‐PRESS ARTifacts toolbox for GABA‐edited MRS

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To create a Python‐based toolbox to simulate commonly occurring artifacts for single voxel gamma‐aminobutyric acid (GABA)‐edited MRS data. Methods The toolbox was designed to maximize user flexibility and contains artifact, applied, input/output (I/O), and support functions.
Hanna Bugler, Amirmohammad Shamaei, Roberto Souza, Ashley D. Harris   +3 more
wiley   +1 more source

Regulation of arginine vasopressin receptors

, 1991
Bibliography: p. 164-191.
openaire   +3 more sources

High‐Throughput Mechanical Characterization of Single Microgel Particles by Fluidic Force Microscopy

Small, EarlyView.
The combination of atomic force microscopy and nanofluidics (FluidFM) allows for a new approach for the mechanical characterization of particulate soft matter in the micrometer regime by inverted nanoindentation. Based on the simplified double contact model, the Young's moduli of microgel particles can be determined much faster than by classical ...
Agnes Specht, Steffen Trippmacher, Nadine Raßmann, Tamino Rößler, Katinka Theis, Krystyna Albrecht, Nicolas Helfricht, Jürgen Groll, Georg Papastavrou   +8 more
wiley   +1 more source

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects

Journal of Pharmacological Sciences, 2009
Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception.
Kenji Honda, Yukio Takano
doaj  

Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). [PDF]

, 1979
Madin-Darby canine kidney (MDCK) cells grown in tissue culture have the morphological properties of distal tubular epithelial cells, form tight junctions, and lack several proximal tubular enzyme markers.
Chuman, LM, Rindler, MJ, Saier, MH, Shaffer, L   +3 more
core  

Mannose Oligosaccharide‐Conjugated In Situ Pore‐Forming Injectable Hydrogels for Rheumatoid Arthritis Treatment by Reprogramming Macrophage Extracellular Vesicles

Small Methods, EarlyView.
Design of an injectable porous hydrogel modulating macrophages and their secreted EVs for joint defect repair in the pathology of rheumatoid arthritis. a) The solution containing HA and CS‐MOS, upon mixing with a crosslinker solution, undergoes porous hydrogel formation with the escape of generated CO₂ gas.
Anan Zhang, Yifan Ma, Yutong Liu, Shiyan Dong, Michelle Najarro Torres, Betty Y.S. Kim, Changsheng Liu, Lili Sun, Yuan Yuan, Wen Jiang   +9 more
wiley   +1 more source

Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells

Biological Research, 2004
A capacitative Ca2+ entry (CCE) pathway, activated by depletion of intracellular Ca2+ stores, is thought to mediate much of the Ca2+ entry evoked by receptors that stimulate phospholipase C (PLC).
COLIN W TAYLOR, ZAHID MONEER
doaj