Results 161 to 170 of about 580,482 (298)

Advances in Cyclic Peptides Targeting G Protein-Coupled Receptors. [PDF]

Chembiochem
Zhou Y, Li N, Zheng JS.
europepmc   +1 more source

Arginine vasopressin in vasodilatory shock: effects on metabolism and beyond

, 2008
PURPOSE OF REVIEW: To describe the effects of arginine vasopressin other than its vasoconstrictive and antidiuretic potential in vasodilatory shock. RECENT FINDINGS: Arginine vasopressin influences substrate metabolism by stimulation of hepatic glucose ...
Dünser, Martin W, Westphal, Martin
core  

Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients—A Post Hoc Bayesian Analysis of the AID‐ICU Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Delirium is clinically classified into hypoactive or hyperactive motoric subtypes, which may have different responses to treatment. We assessed heterogeneity in treatment effects according to baseline motoric subtype in the AID‐ICU trial, which randomised adult ICU patients with delirium to haloperidol versus placebo.
Nina C. Andersen‐Ranberg, Lone Musaeus Poulsen, Anders Perner, Johanna Hästbacka, Matthew Morgan, Giuseppe Citerio, Stine Estrup Damby, Camilla Bekker Mortensen, Marie Oxenbøll Collet, Sven‐Olaf Weber, Anne Sofie Andreasen, Morten Bestle, Bülent Uslu, Helle Scharling Pedersen, Louise Gramstrup Nielsen, Kjeld Damgaard, Troels Bek Jensen, Trine Sommer, Nilanjan Dey, Ole Mathiesen, Anders Granholm   +20 more
wiley   +1 more source

Vaptans: A Narrative Review of Pharmacokinetics, Pharmacogenetics, and Clinical Applications. [PDF]

Cells
Lica-Miler M, Miler K, Kostrzewa-Nowak D, Ciechanowicz A, Brodkiewicz A, Różański J, Stępniewska J.   +6 more
europepmc   +1 more source

Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre‐Specified Secondary Analysis of the TVFR Trial

Clinical Endocrinology, Volume 105, Issue 4, Page 514-518, October 2026.
ABSTRACT Objective Hyponatraemia is a common electrolyte disorder often driven by excess arginine vasopressin (AVP). Copeptin is a stable surrogate marker co‐secreted with AVP. It is unclear whether treatment of hyponatraemia with tolvaptan, an AVP‐V2 receptor antagonist, impacts copeptin.
Annabelle M. Warren, Kay Weng Choy, Rudolf Hoermann, Nicholas Russell, Mathis Grossmann   +4 more
wiley   +1 more source

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

An Integrated Analysis of Manganese Metabolism‐Related Genes and Their Association With Biomarkers, Immune Infiltration, and Clinical Subtypes in Alzheimer's Disease

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
This study investigates the role of manganese metabolism in Alzheimer's disease (AD) pathogenesis. Using integrated bioinformatics and machine learning, four core manganese‐related diagnostic genes (TSPO, PTBP1, GLO1, ACACB) were identified, showing high diagnostic accuracy. The analysis also revealed significant immune microenvironment alterations and
Shengnan Shu, Jiahao Hu, Shanshan Hu, Yefeng Yao   +3 more
wiley   +1 more source

Is thirst the missing physiological link between SGLT2 inhibitors and reduced nephrolithiasis risk? [PDF]

Clin Kidney J
Lombardi M, Beltrami P, Martini B.
europepmc   +1 more source

Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity

Journal of Internal Medicine, Volume 300, Issue 4, Page 513-527, October 2026.
Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Soyeon Park, Min Jeong Park, Hye Won Yang, Jeayeon Park, Su Jong Yu, Seung Shin Park, Man‐Ho Choi, Eun Ju Cho, Jung Hee Kim   +8 more
wiley   +1 more source

The dual role of arginine vasopressin in immune regulation: Balancing immunostimulation and immunosuppression. [PDF]

Brain Behav Immun Health
Weisenseel Z, Glasper ER.
europepmc   +1 more source