Results 51 to 60 of about 23,143 (229)

In vitro binding and receptor-mediated activity of terlipressin at vasopressin receptors V1 and V2

Journal of Experimental Pharmacology, 2017
Khurram Jamil,1 Stephen Chris Pappas,2 Krishna R Devarakonda1 1Clinical Development, Mallinckrodt Pharmaceuticals, Bedminster, 2Orphan Therapeutics, LLC, Lebanon, NJ, USA Abstract: Terlipressin, a synthetic, systemic vasoconstrictor with selective ...
Jamil K, Pappas SC, Devarakonda KR
doaj  

Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family [PDF]

Open Biology, 2015
Neuropeptides are ancient regulators of physiology and behaviour, but reconstruction of neuropeptide evolution is often difficult owing to lack of sequence conservation.
Dean C. Semmens, Isabel Beets, Matthew L. Rowe, Liisa M. Blowes, Paola Oliveri, Maurice R. Elphick   +5 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Vasopressin receptors in health and disease

Kidney International, 1996
The molecular cloning and characterization of receptors for the nonapeptide hormone family vasopressin-oxytocin was rapidly followed by the identification of mutations in the V2 receptor gene segregating with the clinical phenotype in more than a hundred families with X-linked nephrogenic diabetes insipidus.
openaire   +3 more sources

Neuroanatomical evidence that kisspeptin directly regulates isotocin and vasotocin neurons. [PDF]

PLoS ONE, 2013
Neuropeptide kisspeptin has been suggested to be an essential central regulator of reproduction in response to changes in serum gonadal steroid concentrations.
Shinji Kanda, Yasuhisa Akazome, Yuta Mitani, Kataaki Okubo, Yoshitaka Oka   +4 more
doaj   +1 more source

Severe Vasoplegic Syndrome Treated with Angiotensin II and Hemoadsorption Therapy after Cardiac Surgery

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Vasoplegic syndrome (VS) is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). The main pathophysiology mechanism of VS includes a systemic inflammatory response syndrome due to surgical trauma, release of pro‐inflammatory mediators caused by blood contact with foreign surfaces of heart‐lung machine (pump and tubing)
Matteo Lucchelli, Davide Tommaso Andreis, Mattia Gomarasca, Giovanni Mistraletti   +3 more
wiley   +1 more source

Rational Design of Hydrophilic Deep Eutectic Solvents to Outperform Oxidoreductase Activity in Aqueous Media

ChemCatChem, EarlyView.
This study investigates the catalytic performance of alcohol dehydrogenases (ADHs) — including thermostability, specific activity, and kinetics — in mixtures of glycerol‐based deep eutectic solvents (DESs) and aqueous buffers. By elucidating enzyme—DES interactions, the work identifies the outperforming hydrophilic DESs that enhance redox biocatalysis,
Ningning Zhang, Estelle Schwarz, Jan Philipp Bittner, Sven Jakobtorweihen, Irina Smirnova, Pablo Domínguez de María, Selin Kara   +6 more
wiley   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Sodium Excretion in Response to Vasopressin and Selective Vasopressin Receptor Antagonists [PDF]

Journal of the American Society of Nephrology, 2008
The mechanisms by which arginine vasopressin (AVP) exerts its antidiuretic and pressor effects, via activation of V2 and V1a receptors, respectively, are relatively well understood, but the possible associated effects on sodium handling are a matter of controversy.
Nadine Bouby, Lise Bankir, Julie Perucca, Pascale Bardoux, Daniel G. Bichet   +4 more
openaire   +3 more sources

Conivaptan and its role in the treatment of hyponatremia

Drug Design, Development and Therapy, 2009
Jalal K Ghali,1 Jareer O Farah,2 Suleiman Daifallah,3 Hassan A Zabalawi,4 Hammam D Zmily51Detroit Medical Center, Detroit, MI, USA; 2Wayne State University/Detroit Medical Center, Detroit, MI, USA; 3John D Dingell VA Medical Center, Detroit, MI, USA; 4 ...
Jalal K Ghali, Jareer O Farah, Suleiman Daifallah, et al   +3 more
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