Results 51 to 60 of about 50,162 (238)
The challenge hypothesis revisited: Focus on reproductive experience and neural mechanisms. [PDF]
, 2020 Our review focuses on findings from mammals as part of a Special Issue "30th Anniversary of the Challenge Hypothesis". Here we put forth an integration of the mechanisms through which testosterone controls territorial behavior and consider how ...
Marler, Catherine A, Trainor, Brian C
core +1 more source
ChemBioChem, Accepted Article.Flavin‐dependent halogenases (FDHs) carry out substrate‐specific and regioselective halogenation reactions in the biosynthesis of various halogenated natural compounds. Several FDHs convert non‐native substrates in vitro. However, obtaining experimental structures of FDHs with non‐native substrates remains challenging and docking often produces ...
Simon Bork +3 more
wiley +1 more source
Sodium Excretion in Response to Vasopressin and Selective Vasopressin Receptor Antagonists [PDF]
Journal of the American Society of Nephrology, 2008 The mechanisms by which arginine vasopressin (AVP) exerts its antidiuretic and pressor effects, via activation of V2 and V1a receptors, respectively, are relatively well understood, but the possible associated effects on sodium handling are a matter of controversy.
Nadine Bouby +4 more
openaire +3 more sources
ChemBioChem, Accepted Article.Given the essential role of protein‐protein interactions (PPIs) in cellular signalling pathways their selective modulation is of great therapeutic interest. Mimicry of secondary structural protein elements has emerged as a promising strategy, with various scaffolds reproducing recognition surfaces of α‐helical and β‐strand/sheet proteins.
James Luccarelli +4 more
wiley +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Coronary artery vasospasm following coronary artery bypass grafting (CABG) is a rare but potentially life‐threatening complication that can lead to myocardial ischemia, arrhythmias, and cardiogenic shock. Nitroglycerin‐resistant vasospasm, particularly involving the left main coronary artery (LMCA), poses significant diagnostic and ...
Dina Soliman +3 more
wiley +1 more source
Immunocytochemical evidence for vasopressin receptors. [PDF]
Journal of Histochemistry & Cytochemistry, 1978 An electron microscopic study was made of mouse pituitaries immunocytochemically stained with anti-lysine vasopressin (LVP) as the primary antiserum in the unlabeled antibody peroxidase-anti-peroxidase procedure. Vasopressin (VP) was identified in the neurosecretory granules of the neural lobe which stained with peroxidase anti-peroxidase molecules ...
openaire +3 more sources
Chronic alcohol consumption and withdrawal do not induce cell death in the suprachiasmatic nucleus, but lead to irreversible depression of peptide immunoreactivity and mRNA levels [PDF]
, 1997 There is evidence that chronic ethanol treatment (CET) disrupts the biological rhythms of various brain functions and behaviors. Because the suprachiasmatic nucleus (SCN) is widely recognized as the dominant pacemaker of the circadian system, we have ...
Almeida, OFX +5 more
core +1 more source
Chemistry – A European Journal, EarlyView.Herein, a sequential acyl‐thiol‐ene/S‐deacetylation protocol for selective installation of thiol residues onto synthetic peptides, on‐resin, is demonstrated. The hydrothiolation/S‐deacetylation protocol offers a novel synthetic tool for direct peptide conjugation on‐resin and for the preparation of novel disulfide containing neuropeptides displaying ...
Nikita Ostrovitsa +5 more
wiley +1 more source
Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells [PDF]
, 2009 When the succinate receptor (SUCNR1) is activated in the afferent arterioles of the glomerulus it increases renin release and induces hypertension.
Deen +37 more
core +1 more source
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source