Results 81 to 90 of about 23,143 (229)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.

PLoS ONE, 2011
IntroductionCardiovascular agents are pivotal in the therapy of heart failure. Apart from their action on ventricular contractility and systemic afterload, they affect pulmonary arteries and veins. Although these effects are crucial in heart failure with
Annette D Rieg, Rolf Rossaint, Stefan Uhlig, Christian Martin   +3 more
doaj   +1 more source

Congestion, decongestion, renal function and diuretics in (ESC) heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 730-732, April 2025.
Jan Biegus, Piort Gajewski, Piotr Ponikowski   +2 more
wiley   +1 more source

SMART MRS: A Simulated MEGA‐PRESS ARTifacts toolbox for GABA‐edited MRS

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To create a Python‐based toolbox to simulate commonly occurring artifacts for single voxel gamma‐aminobutyric acid (GABA)‐edited MRS data. Methods The toolbox was designed to maximize user flexibility and contains artifact, applied, input/output (I/O), and support functions.
Hanna Bugler, Amirmohammad Shamaei, Roberto Souza, Ashley D. Harris   +3 more
wiley   +1 more source

Therapeutic Potential of Vasopressin-Receptor Antagonists in Heart Failure

Journal of Pharmacological Sciences, 2014
.: Arginine vasopressin (AVP) is a 9-amino acid peptide that is secreted from the posterior pituitary in response to high plasma osmolality and hypotension.
Yasukatsu Izumi, Katsuyuki Miura, Hiroshi Iwao   +2 more
doaj  

A Large Cohort Study to Identify Risk Factors of Acute Kidney Injury in Pediatric Patients Undergoing Intravenous Vancomycin Therapy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Background and Objectives The relative contribution of vancomycin exposure versus clinical factors to acute kidney injury (AKI) development in pediatric patients remains unclear. This study examined risk factors for AKI in pediatric patients receiving intravenous vancomycin therapy, with particular focus on elucidating the role of vancomycin ...
Rahul K. Goyal, Brady S. Moffett, Kristine A. Parbuoni, Emily L. Heil, Jogarao V. S. Gobburu   +4 more
wiley   +1 more source

An Up‐to‐Date Review of Traditional Chinese Medicine in the Treatment of Atherosclerosis: Components, Mechanisms, and Therapeutic Potentials

Phytotherapy Research, EarlyView.
Traditional Chinese medicine in atherosclerosis: multi‐target modulation of pathogenesis. ABSTRACT Atherosclerosis is a chronic inflammatory disease and a major global health concern. In recent years, traditional Chinese medicines (TCMs) have demonstrated multi‐target therapeutic potential against atherosclerosis by modulating inflammatory responses ...
Dilaram Nijat, Qingzhe Zhao, Gulhasal Abdurixit, Jianhua He, Haipeng Liu, Jinyao Li   +5 more
wiley   +1 more source

The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies

Brazilian Journal of Medical and Biological Research, 2000
Recent studies from several groups have indicated that abnormal or ectopic expression and function of adrenal receptors for various hormones may regulate cortisol production in ACTH-independent hypercortisolism.
Lacroix A., N'Diaye N., Mircescu H., Tremblay J., Hamet P.   +4 more
doaj  

Mannose Oligosaccharide‐Conjugated In Situ Pore‐Forming Injectable Hydrogels for Rheumatoid Arthritis Treatment by Reprogramming Macrophage Extracellular Vesicles

Small Methods, EarlyView.
Design of an injectable porous hydrogel modulating macrophages and their secreted EVs for joint defect repair in the pathology of rheumatoid arthritis. a) The solution containing HA and CS‐MOS, upon mixing with a crosslinker solution, undergoes porous hydrogel formation with the escape of generated CO₂ gas.
Anan Zhang, Yifan Ma, Yutong Liu, Shiyan Dong, Michelle Najarro Torres, Betty Y.S. Kim, Changsheng Liu, Lili Sun, Yuan Yuan, Wen Jiang   +9 more
wiley   +1 more source

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Role of the Vasopressin Receptor in Psychological and Cognitive Functions

Journal of Pharmacological Sciences, 2009
Arginine vasopressin (AVP) is a neurohypophyseal peptide best known as an antidiuretic hormone. AVP receptors have been classified into three subtypes: V1a, V1b, and V2 receptors.
Nobuaki Egashira, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara   +4 more
doaj