Results 241 to 250 of about 4,403,902 (351)
Antiretroviral effect of 4-thio-uridylate against human immunodeficiency virus type 1 [PDF]
Albert J.+32 more
core +1 more source
Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang+6 more
wiley +1 more source
Syndecan 2 proteoglycan serves as a hepatitis B virus cell attachment receptor. [PDF]
Tripathi SK, Li Y, Luo G.
europepmc +1 more source
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley +1 more source
Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection. [PDF]
Chen YW+6 more
europepmc +1 more source
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah+9 more
wiley +1 more source
Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma. [PDF]
Wieczfinska J, Pawliczak R.
europepmc +1 more source
Atomic‐Level Engineering of Synthetic Receptors for Enhanced Virus Detection and Removal
Advanced computational techniques are employed to design and optimize computationally designed imprinted receptors (CIRs) for virus detection and removal. CIR‐conjugated piezoelectric sensor achieves highly sensitive virus detection in water and human serum. CIR‐integrated membranes remove 100% of pathogenic viruses from contaminated water.
Eda Akin+8 more
wiley +1 more source