Results 1 to 10 of about 2,348,486 (249)

Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins [PDF]

Viruses
Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to ...
Thomas Marceau, Martine Braibant
doaj   +5 more sources

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Cell Reports, 2019
Summary: Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism.
Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, Daniel Sauter   +20 more
doaj   +3 more sources

Retrovirus-Induced Immunosuppression: Role of the Transmembrane Envelope Protein [PDF]

Viruses
Retroviruses induce immunosuppression in their infected hosts. This phenomenon is well described for the immunodeficiency viruses, with human immunodeficiency virus type 1 (HIV-1) representing the best-studied example, but it also occurs in other ...
Joachim Denner
doaj   +2 more sources

Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry

Emerging Microbes and Infections, 2020
Emerging studies have indicated that some penaeidins restrict virus infection; however, the mechanism(s) involved are poorly understood. In the present study, we uncovered that penaeidins are a novel family of antiviral effectors against white spot ...
Bang Xiao, Qihui Fu, Shengwen Niu, Peng Zhu, Jianguo He, Chaozheng Li   +5 more
doaj   +3 more sources

N-linked glycosylation of GETV envelope proteins affect viral infection and pathogenicity [PDF]

Virulence
Getah virus (GETV) is an emerging mosquito-borne pathogen with a broad host range, posing a significant threat to livestock and public health. Although putative N-linked glycosylation sites on its envelope proteins have been reported, their precise ...
Hui Meng, Tianyi Wang, Chunxiao Mou, Yanmei Huang, Zhenhai Chen   +4 more
doaj   +2 more sources

Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins [PDF]

MAbs, 2017
David Peterhoff, Tim-Henrik Bruun, Benedikt Asbach   +2 more
exaly   +2 more sources

MARCH8 Targets Cytoplasmic Lysine Residues of Various Viral Envelope Glycoproteins

Microbiology Spectrum, 2022
The host transmembrane protein MARCH8 is a RING finger E3 ubiquitin ligase that downregulates various host transmembrane proteins, such as MHC-II. We have recently reported that MARCH8 expression in virus-producing cells impairs viral infectivity by ...
Yanzhao Zhang, Seiya Ozono, Takuya Tada, Minoru Tobiume, Masanori Kameoka, Satoshi Kishigami, Hideaki Fujita, Kenzo Tokunaga   +7 more
doaj   +1 more source

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein

iScience, 2023
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the stability of SARS-CoV ...
Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki   +16 more
doaj   +1 more source

Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage

Emerging Microbes and Infections, 2023
Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped viruses budding and release from the producer cells, viral envelope glycoproteins are presented on the viral membrane surface as spikes, promoting the virus's next-
Changqing Yu, Guosheng Wang, Qiang Liu, Jingbo Zhai, Mengzhou Xue, Qiang Li, Yuanhua Xian, Chunfu Zheng   +7 more
doaj   +1 more source

Yeast two hybrid analyses reveal novel binary interactions between human cytomegalovirus-encoded virion proteins. [PDF]

PLoS ONE, 2011
Human cytomegalovirus (HCMV) is the largest human herpesvirus and its virion contains many viral encoded proteins found in the capsid, tegument, and envelope.
Aaron To, Yong Bai, Ao Shen, Hao Gong, Sean Umamoto, Sangwei Lu, Fenyong Liu   +6 more
doaj   +1 more source