Results 1 to 10 of about 141,815 (162)

Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins [PDF]

Viruses
Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to ...
Thomas Marceau, Martine Braibant
doaj   +6 more sources

MARCH8 Targets Cytoplasmic Lysine Residues of Various Viral Envelope Glycoproteins

Microbiology Spectrum, 2022
The host transmembrane protein MARCH8 is a RING finger E3 ubiquitin ligase that downregulates various host transmembrane proteins, such as MHC-II. We have recently reported that MARCH8 expression in virus-producing cells impairs viral infectivity by ...
Yanzhao Zhang, Seiya Ozono, Takuya Tada, Minoru Tobiume, Masanori Kameoka, Satoshi Kishigami, Hideaki Fujita, Kenzo Tokunaga   +7 more
doaj   +3 more sources

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Cell Reports, 2019
Summary: Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism.
Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, Daniel Sauter   +20 more
doaj   +3 more sources

Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry

Emerging Microbes and Infections, 2020
Emerging studies have indicated that some penaeidins restrict virus infection; however, the mechanism(s) involved are poorly understood. In the present study, we uncovered that penaeidins are a novel family of antiviral effectors against white spot ...
Bang Xiao, Qihui Fu, Shengwen Niu, Peng Zhu, Jianguo He, Chaozheng Li   +5 more
doaj   +3 more sources

Beyond assembly: functions of the coronavirus M protein [PDF]

Virology Journal
Coronaviruses are enveloped RNA viruses from the family Coronaviridae, notable for their crown-like spike glycoproteins. Though historically regarded as inconsequential, recent outbreaks, most notably COVID-19 caused by SARS-CoV-2, highlight their ...
Christopher Kinyanjui Kariuki, Jordi Doijen, Mandeep Kaur Mann, Jiexiong Xie, Marnix Van Loock, Ellen Van Damme   +5 more
doaj   +2 more sources

Viral and cellular determinants of polarized trafficking of viral envelope proteins from insect-specific and insect-vectored viruses in insect midgut and salivary gland cells [PDF]

Journal of Virology
Gary Blissard, Robin Yuan Chen, Jeff Hodgson   +2 more
exaly   +2 more sources

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein

iScience, 2023
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the stability of SARS-CoV ...
Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki   +16 more
doaj   +1 more source

Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage

Emerging Microbes and Infections, 2023
Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped viruses budding and release from the producer cells, viral envelope glycoproteins are presented on the viral membrane surface as spikes, promoting the virus's next-
Changqing Yu, Guosheng Wang, Qiang Liu, Jingbo Zhai, Mengzhou Xue, Qiang Li, Yuanhua Xian, Chunfu Zheng   +7 more
doaj   +1 more source

Embedding a membrane protein into an enveloped artificial viral replica

RSC Chemical Biology, 2022
We demonstrate the embedding membrane protein, Cx43, on the enveloped artificial viral capsid using a cell-free expression system. The embedding of Cx43 on the envelope was evaluated by detection with anti-Cx43 antibody using FCS and TEM.
Hiroto Furukawa, Hiroshi Inaba, Yoshihiro Sasaki, Kazunari Akiyoshi, Kazunori Matsuura   +4 more
openaire   +2 more sources

The Importance of Glycans of Viral and Host Proteins in Enveloped Virus Infection [PDF]

Frontiers in Immunology, 2021
Animal viruses are parasites of animal cells that have characteristics such as heredity and replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid bilayer membrane surrounds them or not. All the membrane proteins of enveloped viruses that function in attachment to target cells or membrane fusion are modified by ...
Yuqing Li, Dongqi Liu, Yating Wang, Wenquan Su, Gang Liu, Weijie Dong   +5 more
openaire   +3 more sources