Results 41 to 50 of about 203,793 (303)

Envelope-Fusion-Syncytium Formation in Microplitis bicoloratus bracovirus Maturation

Viruses, 2022
The viral envelope is essential for virus maturation. Virus-mediated syncytium formations are induced by viral envelope proteins that cause membrane fusion of the infected cells.
Ming-Wu Dai, Kai-Jun Luo
doaj   +1 more source

Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. [PDF]

, 2009
Hepatitis C virus (HCV) entry occurs via a pH- and clathrin-dependent endocytic pathway and requires a number of cellular factors, including CD81, the tight-junction proteins claudin 1 (CLDN1) and occludin, and scavenger receptor class B member I (SR-BI).
Balfe, Peter, Grove, Joe, Hu, Ke, McKeating, Jane A, Mee, Christopher J, Schwarz, Anne K   +5 more
core   +2 more sources

Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation

Viruses, 2022
The HIV-1 envelope glycoprotein (Env) is an essential structural component of the virus, serving as the receptor-binding protein and principal neutralizing determinant. Env trimers are incorporated into developing particles at the plasma membrane of infected cells. Incorporation of HIV-1 Env into particles in T cells and macrophages is regulated by the
Boris Anokhin, Paul Spearman
openaire   +3 more sources

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]

, 2018
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z, Hu, Q, Ke, X, Li, P, Liu, Y, Sun, J, Tan, Z, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +11 more
core   +1 more source

Recombinant Flag-tagged E1E2 glycoproteins from three hepatitis C virus genotypes are biologically functional and elicit cross-reactive neutralizing antibodies in mice [PDF]

, 2018
Hepatitis C virus (HCV) is a globally disseminated human pathogen for which no vaccine is currently available. HCV is highly diverse genetically and can be classified into 7 genotypes and multiple sub-types. Due to this antigenic variation, the induction
Bieńkowska-Szewczyk, Krystyna, Chmielewska, Alicja, Krapchev, Vasil B., Patel, Arvind H., Rychłowska, Malgorzata, Zimmer, Karolina   +5 more
core   +1 more source

The receptors for gibbon ape leukemia virus and amphotropic murine leukemia virus are not downregulated in productively infected cells

Retrovirology, 2011
Background Over the last several decades it has been noted, using a variety of different methods, that cells infected by a specific gammaretrovirus are resistant to infection by other retroviruses that employ the same receptor; a phenomenon termed ...
Eiden Maribeth V, Liu Meihong
doaj   +1 more source

Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein [PDF]

Cell Chemical Biology, 2018
Viral envelope proteins are required for productive viral entry and initiation of infection. Although the humoral immune system provides ample evidence for targeting envelope proteins as an antiviral strategy, there are few pharmacological interventions that have this mode of action.
Melissanne, de Wispelaere, Wenlong, Lian, Supanee, Potisopon, Pi-Chun, Li, Jaebong, Jang, Scott B, Ficarro, Margaret J, Clark, Xuling, Zhu, Jenifer B, Kaplan, Jared D, Pitts, Thomas E, Wales, Jinhua, Wang, John R, Engen, Jarrod A, Marto, Nathanael S, Gray, Priscilla L, Yang   +15 more
openaire   +2 more sources

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]

, 2016
The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW, Binet, D, Bouché, L, Canis, K, Chertova, E, Dell, A, Desrosiers, RC, Haslam, SM, Keele, BF, Lifson, JD, Morris, HR, North, SJ, O'Connor, MJ, Pang, PC, Panico, M, Rahman, D   +15 more
core   +1 more source

Heterogeneous Condensation on Simplified Viral Envelope Protein Structures

ACS Applied Materials & Interfaces
Elucidating the mechanisms of heterogeneous condensation on viral and bacterial envelopes is crucial for understanding biothreat transport phenomena and optimizing capture efficiency in condensation-based detection devices. We investigate the impact of viral envelope geometric parameters [e.g., surface structure pitch-to-diameter ratio (p/d)] due to ...
Kawkab Ahasan, Han Hu, Pranav Shrotriya, Todd A. Kingston   +3 more
openaire   +2 more sources

The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2

Journal of Virology
Porcine reproductive and respiratory syndrome viruses (PRRSVs) are significant pathogens that affect the global swine industry. Its virions consist of a central core composed of nucleocapsid (N) protein, surrounded by multiple distinct viral envelope ...
Yuan-Zhe Bai, Shujie Wang, Yue Sun, Yong-Gang Liu, Hong-Liang Zhang, Qian Wang, Rui Huang, Cui-Hong Rao, Shi-Jia Xu, Zhi-Jun Tian, Tong-Qing An, Xue-Hui Cai, Yan-Dong Tang   +12 more
doaj   +1 more source