Results 51 to 60 of about 141,914 (260)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

How herpes is assembled

eLife
A combination of imaging techniques reveals how herpes simplex virus type 1 assembles within infected cells, highlighting the roles of essential viral proteins in viral assembly and exit.
Dawid S Zyla
doaj   +1 more source

Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and Budding

Viruses, 2022
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spurred unprecedented and concerted worldwide research to curtail and eradicate this pathogen.
Siyu Li, Roya Zandi
doaj   +1 more source

Arterivirus Minor Envelope Proteins Are a Major Determinant of Viral Tropism in Cell Culture [PDF]

Journal of Virology, 2012
ABSTRACT Arteriviruses are enveloped positive-strand RNA viruses for which the attachment proteins and cellular receptors have remained largely controversial. Arterivirus particles contain at least eight envelope proteins, an unusually large number among RNA viruses.
Tian, D.B., Wei, Z.Z., Zevenhoven-Dobbe, J.C., Liu, R.X., Tong, G.Z., Snijder, E.J., Yuan, S.S.   +6 more
openaire   +3 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

TMPRSS2-induced Golgi disruption restricts the incorporation of virus envelope glycoproteins into virions

EMBO Reports
Understanding the relationship between viral proteins and host factors is essential for developing strategies to control virus infections. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells using angiotensin converting enzyme
Sayuri Seki, Shigeyoshi Harada, Akiko Sugimoto-Ishige, Midori Unno, Machie Sakuma, Shinsuke Ito, Hiroyuki Yamamoto, Aki Tanabe, Saori Matsuoka, Chieko Makino-Okamura, Sewon Ki, Hidehiro Fukuyama, Michishige Harada, Kazuya Tsumagari, Koshi Imami, Takashi Saito, Masato Kubo, Tadaki Suzuki, Haruhiko Koseki, Tetsuro Matano, Kosuke Miyauchi   +20 more
doaj   +1 more source

Structural optimization and de novo design of dengue virus entry inhibitory peptides. [PDF]

PLoS Neglected Tropical Diseases, 2010
Viral fusogenic envelope proteins are important targets for the development of inhibitors of viral entry. We report an approach for the computational design of peptide inhibitors of the dengue 2 virus (DENV-2) envelope (E) protein using high-resolution ...
Joshua M Costin, Ekachai Jenwitheesuk, Shee-Mei Lok, Elizabeth Hunsperger, Kelly A Conrads, Krystal A Fontaine, Craig R Rees, Michael G Rossmann, Sharon Isern, Ram Samudrala, Scott F Michael   +10 more
doaj   +1 more source

Structure and Interactions at the Viral Surface of the Envelope Protein E1 of Semliki Forest Virus [PDF]

Structure, 2006
Semliki Forest virus (SFV) is enveloped by a lipid bilayer enclosed within a glycoprotein cage made by glycoproteins E1 and E2. E1 is responsible for inducing membrane fusion, triggered by exposure to the acidic environment of the endosomes. Acidic pH induces E1/E2 dissociation, allowing E1 to interact with the target membrane, and, at the same time ...
Roussel, Alain, Lescar, Julien, Vaney, Marie-Christine, Wengler, Gisela, Wengler, Gerd, Rey, Felix A.   +5 more
openaire   +4 more sources

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

y Human herpesvirus 6 envelope components enriched in lipid rafts: evidence for virion-associated lipid rafts

Virology Journal, 2009
In general, enveloped viruses are highly dependent on their lipid envelope for entry into host cells. Here, we demonstrated that during the course of virus maturation, a significant proportion of human herpesvirus 6 (HHV-6) envelope proteins were ...
Yamanishi Koichi, Huang Honglan, Tang Huamin, Kawabata Akiko, Mori Yasuko   +4 more
doaj   +1 more source