Results 31 to 40 of about 141,914 (260)
Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein [PDF]
ACS Infectious Diseases, 2018 Dengue virus is a major human pathogen that infects over 390 million people annually leading to approximately 500 000 hospitalizations due to severe dengue. Since the only marketed vaccine, Dengvaxia, has recently been shown to increase disease severity in those lacking natural immunity, antivirals to prevent or treat dengue infection represent a ...
Wenlong Lian +8 more
openaire +2 more sources
The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2
Journal of VirologyPorcine reproductive and respiratory syndrome viruses (PRRSVs) are significant pathogens that affect the global swine industry. Its virions consist of a central core composed of nucleocapsid (N) protein, surrounded by multiple distinct viral envelope ...
Yuan-Zhe Bai +12 more
doaj +1 more source
TEGUMENT PROTEINS OF KAPOSI’S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) AND RELATED GAMMA-HERPESVIRUSES
Frontiers in Microbiology, 2012 A herpesvirus virion is composed of a viral genomic DNA-containing capsid surrounded by a viral envelope with glycoprotein spikes on its surface. Located between the capsid and the outer viral envelope is the virion tegument layer.
Narayanan eSathish, Xin eWang, Yan eYuan
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Herpes Simplex Virus Cell Entry Mechanisms: An Update
Frontiers in Cellular and Infection Microbiology, 2021 Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host ...
Krishnaraju Madavaraju +5 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Development and applications of VSV vectors based on cell tropism
Frontiers in Microbiology, 2012 Viral vectors have been available in various fields such as medical and biological research or gene therapy applications. Targeting vectors pseudotyped with distinct viral envelope proteins that influence cell tropism and transfection efficiency is a ...
Hideki eTani +2 more
doaj +1 more source
Envelope Proteins of Hepatitis B Virus: Molecular Biology and Involvement in Carcinogenesis
Viruses, 2021 The envelope of hepatitis B virus (HBV), which is required for the entry to hepatocytes, consists of a lipid bilayer derived from hepatocyte and HBV envelope proteins, large/middle/small hepatitis B surface antigen (L/M/SHBs).
Jun Inoue +3 more
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Heterogeneous Condensation on Simplified Viral Envelope Protein Structures
ACS Applied Materials & InterfacesElucidating the mechanisms of heterogeneous condensation on viral and bacterial envelopes is crucial for understanding biothreat transport phenomena and optimizing capture efficiency in condensation-based detection devices. We investigate the impact of viral envelope geometric parameters [e.g., surface structure pitch-to-diameter ratio (p/d)] due to ...
Kawkab Ahasan +3 more
openaire +2 more sources