Results 11 to 20 of about 144,866 (262)

The hepatitis B virus envelope proteins: Molecular gymnastics throughout the viral life cycle. [PDF]

Annual Review of Virology, 2020
New hepatitis B virions released from infected hepatocytes are the result of an intricate maturation process that starts with the formation of the nucleocapsid providing a confined space where the viral DNA genome is synthesized via reverse transcription.
Bartenschlager, R., Habjanic, J., Schütz, A.K., Seitz, S.   +3 more
core   +4 more sources

The Importance of Glycans of Viral and Host Proteins in Enveloped Virus Infection [PDF]

Frontiers in Immunology, 2021
Animal viruses are parasites of animal cells that have characteristics such as heredity and replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid bilayer membrane surrounds them or not. All the membrane proteins of enveloped viruses that function in attachment to target cells or membrane fusion are modified by ...
Yuqing Li, Dongqi Liu, Yating Wang, Wenquan Su, Gang Liu, Weijie Dong   +5 more
openaire   +3 more sources

Embedding a membrane protein into an enveloped artificial viral replica

RSC Chemical Biology, 2022
We demonstrate the embedding membrane protein, Cx43, on the enveloped artificial viral capsid using a cell-free expression system. The embedding of Cx43 on the envelope was evaluated by detection with anti-Cx43 antibody using FCS and TEM.
Hiroto Furukawa, Hiroshi Inaba, Yoshihiro Sasaki, Kazunari Akiyoshi, Kazunori Matsuura   +4 more
openaire   +2 more sources

Structure and Role of O-Linked Glycans in Viral Envelope Proteins

Annual Review of Virology, 2023
N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-glycan heterogeneity.
Olofsson, Sigvard, Bally, Marta, Trybala, Edward, Bergström, Tomas   +3 more
openaire   +3 more sources

Nucleocapsid-Independent Specific Viral RNA Packaging via Viral Envelope Protein and Viral RNA Signal [PDF]

Journal of Virology, 2003
ABSTRACT For any of the enveloped RNA viruses studied to date, recognition of a specific RNA packaging signal by the virus's nucleocapsid (N) protein is the first step described in the process of viral RNA packaging. In the murine coronavirus a selective interaction between the viral transmembrane envelope protein M and the viral
Narayanan, K, Chen, CJ, Maeda, J, Makino, S   +3 more
openaire   +2 more sources

Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis

Journal of Virology, 2020
Flaviviruses encode one, two, or no N -linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication.
Derek L. Carbaugh, Helen M. Lazear
openaire   +3 more sources

Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein [PDF]

Cell Chemical Biology, 2018
Viral envelope proteins are required for productive viral entry and initiation of infection. Although the humoral immune system provides ample evidence for targeting envelope proteins as an antiviral strategy, there are few pharmacological interventions that have this mode of action.
Melissanne, de Wispelaere, Wenlong, Lian, Supanee, Potisopon, Pi-Chun, Li, Jaebong, Jang, Scott B, Ficarro, Margaret J, Clark, Xuling, Zhu, Jenifer B, Kaplan, Jared D, Pitts, Thomas E, Wales, Jinhua, Wang, John R, Engen, Jarrod A, Marto, Nathanael S, Gray, Priscilla L, Yang   +15 more
openaire   +2 more sources

The Simian Virus 40 Late Viral Protein VP4 Disrupts the Nuclear Envelope for Viral Release [PDF]

Journal of Virology, 2012
ABSTRACT Simian virus 40 (SV40) appears to initiate cell lysis by expressing the late viral protein VP4 at the end of infection to aid in virus dissemination. To investigate the contribution of VP4 to cell lysis, VP4 was expressed in mammalian cells where it was predominantly observed along the nuclear periphery.
Kristina M, Giorda, Smita, Raghava, Daniel N, Hebert   +2 more
openaire   +2 more sources

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins [PDF]

Nature Communications, 2019
AbstractLipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes.
El Omari, K, Li, S, Kotecha, A, Walter, T, Bignon, E, Harlos, K, Somerharju, P, De Haas, F, Clare, D, Molin, M, Hurtado, F, Li, M, Grimes, J, Bamford, D, Tischler, N, Huiskonen, J, Stuart, D, Roine, E   +17 more
openaire   +4 more sources

Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein [PDF]

ACS Infectious Diseases, 2018
Dengue virus is a major human pathogen that infects over 390 million people annually leading to approximately 500 000 hospitalizations due to severe dengue. Since the only marketed vaccine, Dengvaxia, has recently been shown to increase disease severity in those lacking natural immunity, antivirals to prevent or treat dengue  infection represent a ...
Wenlong Lian, Jaebong Jang, Supanee Potisopon, Pi-Chun Li, Amal Rahmeh, Jinhua Wang, Nicholas P. Kwiatkowski, Nathanael S. Gray, Priscilla L. Yang   +8 more
openaire   +2 more sources