Cell Reports, 2019 Summary: Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism.
Elisabeth Braun +20 more
doaj +3 more sources
Yeast two hybrid analyses reveal novel binary interactions between human cytomegalovirus-encoded virion proteins. [PDF]
PLoS ONE, 2011 Human cytomegalovirus (HCMV) is the largest human herpesvirus and its virion contains many viral encoded proteins found in the capsid, tegument, and envelope.
Aaron To +6 more
doaj +1 more source
Structure and Role of O-Linked Glycans in Viral Envelope Proteins
Annual Review of Virology, 2023 N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-glycan heterogeneity.
Olofsson, Sigvard +3 more
openaire +3 more sources
Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis
Journal of Virology, 2020 Flaviviruses encode one, two, or no N -linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication.
Derek L. Carbaugh, Helen M. Lazear
openaire +3 more sources
Cell type-specific delivery by modular envelope design
Nature Communications, 2023 The delivery of genetic cargo remains one of the largest obstacles to the successful translation of experimental therapies, in large part due to the absence of targetable delivery vectors.
Daniel Strebinger +5 more
doaj +1 more source
The Simian Virus 40 Late Viral Protein VP4 Disrupts the Nuclear Envelope for Viral Release [PDF]
Journal of Virology, 2012 ABSTRACT Simian virus 40 (SV40) appears to initiate cell lysis by expressing the late viral protein VP4 at the end of infection to aid in virus dissemination. To investigate the contribution of VP4 to cell lysis, VP4 was expressed in mammalian cells where it was predominantly observed along the nuclear periphery.
Kristina M, Giorda +2 more
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Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]
, 2014 The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis +1 more
core +4 more sources
HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion
Viruses, 2019 Without viral envelope proteins, viruses cannot enter cells to start infection. As the major viral proteins present on the surface of virions, viral envelope proteins are a prominent target of the host immune system in preventing and ultimately ...
Saina Beitari +3 more
doaj +1 more source
The Hepatitis B Virus Envelope Proteins: Molecular Gymnastics Throughout the Viral Life Cycle [PDF]
Annual Review of Virology, 2020 New hepatitis B virions released from infected hepatocytes are the result of an intricate maturation process that starts with the formation of the nucleocapsid providing a confined space where the viral DNA genome is synthesized via reverse transcription.
Seitz, S. +3 more
openaire +3 more sources
The Importance of Glycans of Viral and Host Proteins in Enveloped Virus Infection [PDF]
Frontiers in Immunology, 2021 Animal viruses are parasites of animal cells that have characteristics such as heredity and replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid bilayer membrane surrounds them or not. All the membrane proteins of enveloped viruses that function in attachment to target cells or membrane fusion are modified by ...
Yuqing Li +5 more
openaire +3 more sources