Results 71 to 80 of about 203,793 (303)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery

Retrovirology, 2018
The InterFeron Induced TransMembrane (IFITM) proteins are interferon stimulated genes that restrict many viruses, including HIV-1. SAMHD1 is another restriction factor blocking replication of HIV-1 and other viruses.
Ferdinand Roesch, Molly OhAinle, Michael Emerman   +2 more
doaj   +1 more source

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins [PDF]

Nature Communications, 2019
AbstractLipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes.
El Omari, K, Li, S, Kotecha, A, Walter, T, Bignon, E, Harlos, K, Somerharju, P, De Haas, F, Clare, D, Molin, M, Hurtado, F, Li, M, Grimes, J, Bamford, D, Tischler, N, Huiskonen, J, Stuart, D, Roine, E   +17 more
openaire   +4 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions [PDF]

, 2012
Herpes viruses are prevalent and well characterized human pathogens. Despite extensive study, much remains to be learned about the structure of the genome packaging and release machinery in the capsids of these large and complex double-stranded DNA ...
Corey W. Hecksel, David Bhella, Frazer J. Rixon, Joel D. Baines, Michael F. Schmid, Ryan H. Rochat, Wah Chiu   +6 more
core   +7 more sources

How herpes is assembled

eLife
A combination of imaging techniques reveals how herpes simplex virus type 1 assembles within infected cells, highlighting the roles of essential viral proteins in viral assembly and exit.
Dawid S Zyla
doaj   +1 more source

Structural optimization and de novo design of dengue virus entry inhibitory peptides. [PDF]

PLoS Neglected Tropical Diseases, 2010
Viral fusogenic envelope proteins are important targets for the development of inhibitors of viral entry. We report an approach for the computational design of peptide inhibitors of the dengue 2 virus (DENV-2) envelope (E) protein using high-resolution ...
Joshua M Costin, Ekachai Jenwitheesuk, Shee-Mei Lok, Elizabeth Hunsperger, Kelly A Conrads, Krystal A Fontaine, Craig R Rees, Michael G Rossmann, Sharon Isern, Ram Samudrala, Scott F Michael   +10 more
doaj   +1 more source

Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola, Ralph Steinman, Richter C. King, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

Arterivirus Minor Envelope Proteins Are a Major Determinant of Viral Tropism in Cell Culture [PDF]

Journal of Virology, 2012
ABSTRACT Arteriviruses are enveloped positive-strand RNA viruses for which the attachment proteins and cellular receptors have remained largely controversial. Arterivirus particles contain at least eight envelope proteins, an unusually large number among RNA viruses.
Tian, D.B., Wei, Z.Z., Zevenhoven-Dobbe, J.C., Liu, R.X., Tong, G.Z., Snijder, E.J., Yuan, S.S.   +6 more
openaire   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source