Results 71 to 80 of about 399,510 (314)

RNA Viruses, Toll-Like Receptors, and Cytokines: The Perfect Storm?

Journal of Innate Immunity
Background: The interactions between viruses and the host immune response are nuanced and intricate. The cytokine response arguably plays a central role in dictating the outcome of virus infection, balancing inflammation, and healing, which is
Sophia K. Stegeman, Olena Kourko, Heather Amsden, Isabella E. Pellizzari Delano, John E. Mamatis, Madison Roth, Che C. Colpitts, Katrina Gee   +7 more
doaj   +1 more source

Cellular Receptors Involved in KSHV Infection

Viruses, 2021
The process of Kaposi’s Sarcoma Herpes Virus’ (KSHV) entry into target cells is complex and engages several viral glycoproteins which bind to a large range of host cell surface molecules. Receptors for KSHV include heparan sulphate proteoglycans (HSPGs),
Emma van der Meulen, Meg Anderton, Melissa J. Blumenthal, Georgia Schäfer   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus

Cell Reports, 2019
Summary: JC polyomavirus (JCPyV) is a ubiquitous human pathogen that causes progressive multifocal leukoencephalopathy (PML). The entry receptors for JCPyV belong to the 5-hydroxytryptamine 2 receptor (5-HT2R) family, but how individual members of the ...
Benedetta Assetta, Jenna Morris-Love, Gretchen V. Gee, Abigail L. Atkinson, Bethany A. O’Hara, Melissa S. Maginnis, Sheila A. Haley, Walter J. Atwood   +7 more
doaj   +1 more source

Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957. [PDF]

PLoS ONE, 2010
Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin (HA) warrants investigation of ...
Claudia Pappas, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Jacqueline M Katz, Ram Sasisekharan, Terrence M Tumpey   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus [PDF]

, 1998
Recently, myxoma virus was shown to encode an additional member of the serpin superfamily. The viral gene, called serp2, was cloned, and the Serp2 protein was shown to specifically bind to interleukin-1beta (IL-1beta)-converting enzyme (ICE), thus ...
Messud-Petit, Frédérique, Py, Robert, Gelfi, Jacqueline, Amardeilh, Marie France, Bertagnoli, Stéphane, Sutter, Gerd, Delverdier, Maxence   +6 more
core  

Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis

, 2012
Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are
Killip, M. J., Randall, RE, Goodbourn, S., Precious, BL, Young, D. F., Precious, B. L., Randall, R. E., S. Goodbourn, Goodbourn, S, D. F. Young, R. E. Randall, M. J. Killip, Young, DF, Killip, MJ, B. L. Precious   +14 more
core   +1 more source

Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands. [PDF]

, 2010
Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability.
Marcinowski, Lisa, Lars Dölken, Astrid Krmpotic, Jonjic, S. (Stipan), Kothe, Sheila, Ruzsics, Zsolt, Tanguy Mélanie, Koszinowski, Ulrich H, Dölken Lars, Krmpotic Astrid, Zsolt Ruzsics, Ruzsics, Z. (Zsolt), Tuddenham, L. (Lee), Jonjic Stipan, Elefant, N. (Naama), Tanguy, Mélanie, Elefant Naama, Pfeffer, S. (Sebastien), Koszinowski, U. (Ulrich H), Marcinowski Lisa, Lisa Marcinowski, Elefant, Naama, Ulrich H Koszinowski, Tuddenham Lee, Altuvia, Yael, Koszinowski Ulrich H., Lee Tuddenham, Stipan Jonjic, Pfeffer Sébastien, Altuvia, Y. (Yael), Kothe Sheila, Sébastien Pfeffer, Tuddenham, Lee, Mélanie Tanguy, Margalit, Hanah, Ruzsics Zsolt, Margalit Hanah, Marcinowski, L. (Lisa), Krmpotic, A. (Astrid), Koszinowski, Ulrich H., Dölken, L. (Lars), Tanguy, M. (Mélanie), Krmpotic, Astrid, Sheila Kothe, Dölken, Lars, Ulrich H. Koszinowski, Yael Altuvia, Naama Elefant, Pfeffer, Sébastien, Kothe, S. (Sheila), Hanah Margalit, Altuvia Yael, Jonjic, Stipan, Margalit, H. (Hanah)   +53 more
core   +1 more source

Zika Virus Structure, Maturation, and Receptors [PDF]

The Journal of Infectious Diseases, 2017
The emergence of Zika virus (ZIKV) as a major public health threat has focused research on understanding virus biology and developing a suite of strategies for disease intervention. Recent advances in cryoelectron microscopy have accelerated structure-function studies of flaviviruses and of ZIKV in particular. Structures of the mature and immature ZIKV
Devika, Sirohi, Richard J, Kuhn
openaire   +2 more sources