Results 61 to 70 of about 609,928 (307)

Is the TAM Receptor Axl a Receptor for Lymphocytic Choriomeningitis Virus? [PDF]

Journal of Virology, 2013
ABSTRACT A recent publication indicated that overexpression of Axl, a cellular receptor that negatively regulates Toll-like receptor signaling, enhanced the entry of viruses pseudotyped with the glycoprotein of lymphocytic choriomeningitis virus (LCMV) in vitro .
Brian M, Sullivan, Megan J, Welch, Greg, Lemke, Michael B A, Oldstone   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Flavivirus Entry Receptors: An Update

Viruses, 2013
Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with cell surface receptors. The current model suggests that flaviviruses use at least two different sets of molecules for infectious entry: attachment factors that ...
Manuel Perera-Lecoin, Laurent Meertens, Xavier Carnec, Ali Amara   +3 more
doaj   +1 more source

Cellular Receptors Involved in KSHV Infection

Viruses, 2021
The process of Kaposi’s Sarcoma Herpes Virus’ (KSHV) entry into target cells is complex and engages several viral glycoproteins which bind to a large range of host cell surface molecules. Receptors for KSHV include heparan sulphate proteoglycans (HSPGs),
Emma van der Meulen, Meg Anderton, Melissa J. Blumenthal, Georgia Schäfer   +3 more
doaj   +1 more source

Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines. [PDF]

, 1993
Because human lymphotoxin (LT) was originally isolated from a lymphoblastoid cell line, we investigated the role of this molecule in three newly established Epstein-Barr virus (EBV)-infected human B cell lines.
Aggarwal, BB, Estrov, Z, Harris, D, Kantarjian, HM, Kurzrock, R, Pathak, S, Pocsik, E, Talpaz, M, Zipf, TF   +8 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957. [PDF]

PLoS ONE, 2010
Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin (HA) warrants investigation of ...
Claudia Pappas, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Jacqueline M Katz, Ram Sasisekharan, Terrence M Tumpey   +6 more
doaj   +1 more source

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology [PDF]

, 2020
Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections. Whether such therapies are efficient during an acute infection remains elusive.
Akhmetzyanova, Ilseyar [u.v.m.], David, Paul David, Drabczyk-Pluta, Malgorzata, Gruber, Achim D., Honke, Nadine, Kershaw, Olivia, Knuschke, Torben, Megger, Dominik A., Pastille, Eva, Werner, Tanja   +9 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Cellular receptors for mammalian viruses.

PLoS Pathogens
The interaction of viral surface components with cellular receptors and other entry factors determines key features of viral infection such as host range, tropism and virulence.
Ana Valero-Rello, Carlos Baeza-Delgado, Iván Andreu-Moreno, Rafael Sanjuán   +3 more
doaj   +1 more source