Results 91 to 100 of about 2,009,256 (317)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo

, 2009
Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Brugger, Stefan, Stefan Brugger, Martina Kurejova, Tegeder Imgard, Gangadharan Vijayan, Imgard Tegeder, Gangadharan, Vijayan, Tegeder, Irmgard, Kuner Rohini, Kurejova, Martina, Rohini Kuner, Kurejova Martina, Nitin Agarwal, Bernhard Bettler, Brugger Stefan, Vijayan Gangadharan, Tegeder, Imgard, Agarwal, Nitin, Bettler Bernhard, Bettler, Bernhard, Agarwal Nitin, Kuner, Rohini   +21 more
core   +1 more source

Ethylene signalling receptors and transcription factors over the grape berry development: gene expression profiling [PDF]

, 2010
The ethylene signalling pathway has never been fully described in grapes. Regarded as a non-climacteric fruit, grape berry seems to ripen independently to ethylene, however 1-methylcyclopropene (1-MCP), a specific inhibitor of ethylene receptors has been
Chervin, Christian, Chervin, D., Deluc, Laurent, Deluc, L., Chervin, C.   +4 more
core   +1 more source

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

eLife
The serotonin-gated ion channel (5-HT3R) mediates excitatory neuronal communication in the gut and the brain. It is the target for setrons, a class of competitive antagonists widely used as antiemetics, and is involved in several neurological diseases ...
Laurie Peverini, Sophie Shi, Karima Medjebeur, Pierre-Jean Corringer   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity

, 2003
A reduction in microglial activation and subsequent neurotoxicity may prove critical for neuroprotection in neurodegenerative diseases. We examined the expression and functionality of group III metabotropic glutamate (mGlu) receptors on microglia.
Taylor, D.L., Pocock, J.M., Diemel, L.T.
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Purinergic receptors in skeletal muscles in health and in muscular dystrophy

, 2014
The P2 purinergic (nucleotide) receptor super-family comprises of two families of protein. The P2X, which are channel-forming ionotropic receptors and the P2Y metabotropic receptors activating G protein-mediated signalling pathways.
Young, Christopher, Zablocki, Krzysztof, Rog, Justyna, Young, Christopher N. J., Rog, J., Gorecki, Dariusz, Zablocki, K., Krasowska, Elzbieta, Sinadinos, Anthony, Gorecki, Darek, Krasowska, E.   +10 more
core  

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Buwalda, Bauke, Vegt, Bea J. van der,, van der Vegt, BJ, Ruiter, Anne J.H. de,, Jong, Jelly G. de,, Koolhaas, J.M., de Ruiter, Anne J.H., Bauke Buwalda, Sietse F de Boer, Koolhaas, Jaap M.,, van der Vegt, Bea J., de Jong, Jelly G., Koolhaas, JM, de Boer, SF, de Jong, JG, Buwalda, Bauke,, Buwalda, B, Bea J van der Vegt, Boer, Sietse F. de,, Anne J.H de Ruiter, Jelly G de Jong, de Boer, Sietse F., Jaap M Koolhaas, de Ruiter, AJH   +23 more
core   +1 more source