Results 131 to 140 of about 2,009,256 (317)

The Binding and Effects of Boron-Containing Compounds on G Protein-Coupled Receptors: A Scoping Review

Receptors
Boron-containing compounds (BCCs) have emerged as potential drugs. Their drug-like effects are mainly explained by their mechanisms of action in enzymes.
José M. Santiago-Quintana, Alina Barquet-Nieto, Bhaskar C. Das, Rafael Barrientos-López, Melvin N. Rosalez, Ruth M. Lopez-Mayorga, Marvin A. Soriano-Ursúa   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core  

The State-of-the-Art Review on FSHR, LHCGR, AR, ESR1, and ESR2 Key Mutations and Their Impact on the Effectiveness of Infertility Therapies—What We Know So Far

Receptors
Mutations in hormone receptors significantly influence infertility and the outcomes of assisted reproductive technologies (ART). This review explores the functional interplay among mutations in FSHR, LHCGR, AR, ESR1, and ESR2 hormone receptors and their ...
Daniela Hristov, Done Stojanov
doaj   +1 more source

Bioinformatics and mathematical modelling in the study of receptor-receptor interactions and receptor oligomerization: focus on adenosine receptors.

Biochimica et biophysica acta, 2011
The concept of intra-membrane receptor-receptor interactions (RRIs) between different types of G protein-coupled receptors (GPCRs) and evidence for their existence was introduced by Agnati and Fuxe in 1980/81 through the biochemical analysis of the effects of neuropeptides on the binding characteristics of monoamine receptors in membrane preparations ...
GUIDOLIN, DIEGO, Ciruela F, Genedani S, Guescini M, TORTORELLA, CINZIA, ALBERTIN, GIOVANNA, Fuxe K, Agnati LF   +7 more
openaire   +5 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Frizzled Proteins are bona fide G Protein-Coupled Receptors

, 2009
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core  

G-Protein-Coupled Receptor Kinase 2 Limits CCL21-Induced T Cell Migration via Phospholipase Cγ1

Receptors
Background/Objectives: G protein-coupled receptors (GPCRs) can promote ligand-biased signaling, yet the mechanisms that promote bias are not well understood.
Anahi Sanchez, Caitlin T. Winebrenner, Natalia Garcia, Brian Kaiser, Lyndsey Kilgore, Cesar I. Cardona, Daniel W. Bassuk, Mary E. Miller, Charles A. Bill, Laura A. Shannon, Brant M. Wagener, Amy Wagler, Manuel Llano, Colin A. Bill, Charlotte M. Vines   +14 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The GLI3–Androgen Receptor Axis: A Feedback Circuit Sustaining Shh Signaling in Prostate Cancer

Receptors
The Hedgehog (Hh) signaling pathway regulates key cellular processes, such as proliferation, differentiation, and morphogenesis. Although its canonical activation involves ligand binding to PTCH1, which activates Smoothened (SMO), noncanonical features ...
Stephanie I. Nuñez-Olvera, Enoc Mariano Cortés-Malagón, Isela Montúfar-Robles, José Javier Flores-Estrada, María Elizbeth Alvarez-Sánchez, Jonathan Puente-Rivera   +5 more
doaj   +1 more source