Results 161 to 170 of about 3,480,967 (280)

Glutamate as a Therapeutic Substrate in Migraine. [PDF]

Int J Mol Sci
Karsan N, Luiza Bastos A, Goadsby PJ.
europepmc   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

INFLUENCE OF ADRENERGIC BETA‐RECEPTOR BLOCKADE ON THE ACUTE CARDIOVASCULAR EFFECTS OF HYDRALAZINE* [PDF]

, 1967
H. Brünner, P. R. Hedwall, Max Meier
openalex   +1 more source

Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain. [PDF]

BMC Anesthesiol
Szczupak M, Kobak J, Cimoszko-Zauliczna M, Krupa-Nurcek S, Ingielewicz A, Wierzchowska J.   +5 more
europepmc   +1 more source

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

Molecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, Sebastià Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto   +14 more
wiley   +1 more source

The response of the chemical receptors of the carotid sinus to the tension of CO₂ in the arterial blood in the cat1

, 1935
Adli Samaan, G. Stella
openalex   +2 more sources

Differential Effects of Hearing Loss Mutations in Homomeric P2X2 and Heteromeric P2X2/3 Receptors. [PDF]

Cells
Wand PL, Brünings X, Tewari D, Reuter S, Mrowka R, Benndorf K, Zimmer T, Sattler C.   +7 more
europepmc   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, Volume 19, Issue 5, Page 1517-1531, May 2025.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

The excitation of touch receptors in frog's skin

, 1951
J.A. Gray, John Malcolm
openalex   +2 more sources

THE EFFECTS ON CARDIAC MUSCLE OF β‐RECEPTOR ANTAGONISTS IN RELATION TO THEIR ACTIVITY AS LOCAL ANAESTHETICS [PDF]

, 1965
A Morales-Aguilera, E. M. Vaughan Williams   +1 more
openalex   +1 more source