Results 251 to 260 of about 2,009,256 (317)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Accurate computation of ionic concentrations in the synaptic cleft requires the full Poisson-Nernst-Planck (PNP) equations. [PDF]

PLoS Comput Biol
Jæger KH, Tveito A.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Molecular and Computational Basis of Taste Perception: A Review toward the "Digital Language of Taste". [PDF]

ACS Omega
Ashikhmina MS, Dutta K, Normatov S, Filozop VS, Volodarskiy MO, Volkova O, Ulasevich SA, Skorb EV.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Pregabalin Depresses Cerebellar Parallel Fiber-Purkinje Cell Synaptic Transmission by Modulating Glun2a-Containing Nmda Receptors in Mice In Vitro. [PDF]

Int J Mol Sci
Li MR, Zhang XD, Chen L, Zhang YD, Wang CY, Zhao ZY, Zhou M, Chu CP, Qiu DL.   +8 more
europepmc   +1 more source

Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors. [PDF]

Nat Commun
Kahlous NA, Rinne MK, Zhang X, Li Y, Chen Y, Motso A, Gao K, Bergqvist C, Sheng H, Wang Y, Cabeza de Vaca I, Díaz-Holguín A, Ullmann P, Bengtsson T, Lauschke VM, Kukkonen JP, Delemotte L, Wright SC, Liu X, Larhammar D, Carlsson J.   +20 more
europepmc   +1 more source

A biophysically grounded model of glutamatergic synaptic transmission integrating glutamate transport, receptor kinetics, and electrotonic effects. [PDF]

J Comput Neurosci
Chizhov AV, Malkin SL, Khachatryan DN, Zaitsev AV.   +3 more
europepmc   +1 more source

A complex interplay of various intracellular motifs determines G protein binding and activation of muscarinic receptors. [PDF]

Sci Rep
Kirchhofer SB, Jelinek V, Klingelhöfer K, Krett AL, Bünemann M.   +4 more
europepmc   +1 more source

Spinal and supraspinal mechanisms of chronic itch: from neuronal circuits to the neuro-immune-microbial axis. [PDF]

Front Med (Lausanne)
Gao S, Liu M, Qi Z, Li Y, Xue Y, Gao C.
europepmc   +1 more source