Results 41 to 50 of about 89,607 (287)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Risque de cancer de la prostate par profession dans le Système de surveillance des maladies professionnelles de l’Ontario, Canada

open access: yesPromotion de la santé et prévention des maladies chroniques au Canada, 2019
Introduction. Des études épidémiologiques canadiennes ont permis d’établir des liens entre certaines professions et le risque de cancer de la prostate, mais avec des données probantes limitées.
Jeavana Sritharan   +4 more
doaj   +1 more source

Les effets du recours au numérique sur un dispositif d’intervention et de formation à la démarche de recherche-action de collectifs d’inspecteurs et de formateurs de l’éducation en Afrique

open access: yesMédiations & Médiatisations, 2023
Cet article propose une analyse de la manière dont une ingénierie d’intervention auprès d’acteurs de huit pays d’Afrique impliqués dans un programme d’appui au pilotage de la qualité de l’éducation de base a fait le choix d’évoluer vers un appui à ...
Brian Beghe, Thierry Hug
doaj   +1 more source

Utiliser une recherche-action comme étape d'une innovation [PDF]

open access: yes, 2009
Peer ...
Absil, Gaëtan, Vandoorne, Chantal
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

A Multiplex Serological Assay to Evaluate the Antibody Responses to a Set of Plasmodium falciparum Antigens and Their Protective Role Against Malaria in Children Aged 1.5 to 12 Years Living in a Highly Seasonal Malaria Transmission Area of Burkina Faso

open access: yesVaccines
Background/Objectives: Understanding the seroepidemiology of P. falciparum antibody responses is essential for assessing the acquisition of natural immunity and may guide interventions that impact the acquisition of immunity against malaria in endemic ...
Sem Ezinmegnon   +10 more
doaj   +1 more source

Leçons d'une expérience de recherche-action appliquée à l'accompagnement [PDF]

open access: yes, 2010
La communication analyse comment a été élaborée et menée une recherche-action portant sur l'accompagnement des porteurs de projet pluriactifs dans le Haut Languedoc (Hérault), et questionne, au sein du projet, la double posture du chercheur placé en ...
Tallon, Hélène
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Formation des enseignants: un exemple de recherche-action: Chypre, France, lrlande, République tchèque, Slovénie [PDF]

open access: yes, 2009
Cet article rend compte d’un travail de recherche engagé par des universitaires de cinq pays, dans le cadre d’un projet européen sur l’enseignement des sciences.
Gash, Hugh   +3 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

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