African-specific polymorphisms in Plasmodium falciparum serine repeat antigen 5 in Uganda and Burkina Faso clinical samples do not interfere with antibody response to BK-SE36 vaccination [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 BK-SE36, based on Plasmodium falciparum serine repeat antigen 5 (SERA5), is a blood-stage malaria vaccine candidate currently being evaluated in clinical trials.
Nobuko Arisue +2 more
exaly +7 more sources
Age-dependent carriage of alleles and haplotypes of Plasmodium falciparum sera5, eba-175, and csp in a region of intense malaria transmission in Uganda [PDF]
Malaria Journal, 2020 Background The development of malaria vaccines is constrained by genetic polymorphisms exhibited by Plasmodium falciparum antigens. The project the age-dependent distribution of alleles or haplotypes of three P.
Constance Agwang, Joseph Erume
exaly +7 more sources
Protective Epitopes of the Plasmodium falciparum SERA5 Malaria Vaccine Reside in Intrinsically Unstructured N-Terminal Repetitive Sequences [PDF]
PLoS ONE, 2014 The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we have previously shown the inhibitory effects of SE36 specific antibodies on in ...
Takahiro Tougan +2 more
exaly +5 more sources
PLoS Pathogens, 2017 Egress of the malaria parasite Plasmodium falciparum from its host red blood cell is a rapid, highly regulated event that is essential for maintenance and completion of the parasite life cycle.
Christine R Collins +2 more
exaly +5 more sources
Assessment of Mixed Plasmodium falciparum sera5 Infection in Endemic Burkitt Lymphoma: A Case-Control Study in Malawi. [PDF]
Cancers (Basel), 2021 Background: Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in Africa and is linked to Plasmodium falciparum (Pf) malaria infection, one of the most common and deadly childhood infections in Africa; however, the role of Pf genetic ...
Arisue N +16 more
europepmc +9 more sources
P lasmodium falciparum SERA 5 plays a non‐enzymatic role in the malarial asexual blood‐stage lifecycle [PDF]
Molecular Microbiology, 2015 The malaria parasite Plasmodium falciparum replicates in an intraerythrocytic parasitophorous vacuole (PV). The most abundant P. falciparum PV protein, called SERA5, is essential in blood stages and possesses a papain-like domain, prompting speculation ...
Chrislaine Withers-Martinez +2 more
exaly +8 more sources
Characteristic features of the SERA multigene family in the malaria parasite [PDF]
Parasites & Vectors, 2020 Serine repeat antigen (SERA) is conserved among species of the genus Plasmodium. Sera genes form a multigene family and are generally tandemly clustered on a single chromosome. Although all Plasmodium species encode multiple sera genes, the number varies
Nobuko Arisue +3 more
doaj +2 more sources
Plasmodium falciparum infection coinciding with the malaria vaccine candidate BK-SE36 administration interferes with the immune responses in Burkinabe children [PDF]
Frontiers in Immunology, 2023 BackgroundA vaccine targeting the erythrocyte stages of Plasmodium falciparum could play a role in preventing clinical disease. BK-SE36 is a promising malaria vaccine candidate that has shown a good safety profile and immunological responses during field
Alfred B. Tiono +10 more
doaj +2 more sources
Enzymic, Phylogenetic, and Structural Characterization of the Unusual Papain-like Protease Domain of Plasmodium falciparum SERA5 [PDF]
Journal of Biological Chemistry, 2003 Serine repeat antigen 5 (SERA5) is an abundant antigen of the human malaria parasite Plasmodium falciparum and is the most strongly expressed member of the nine-gene SERA family. It appears to be essential for the maintenance of the erythrocytic cycle, unlike a number of other members of this family, and has been implicated in parasite egress and/or ...
Mauro Delorenzi +2 more
exaly +3 more sources
Molecular Camouflage of Plasmodium falciparum Merozoites by Binding of Host Vitronectin to P47 Fragment of SERA5 [PDF]
Scientific Reports, 2018 AbstractThe malaria parasitePlasmodium falciparumproliferates in the blood stream where the host immune system is most active. To escape from host immunity,P. falciparumhas developed a number of evasion mechanisms. Serine repeat antigen 5 (SERA5) is a blood stage antigen highly expressed at late trophozoite and schizont stages.
Takahiro Tougan +2 more
exaly +3 more sources