Results 11 to 20 of about 5,820 (141)

Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes [PDF]

Scientific Reports, 2019
Abstract Pseudokinases play key roles in many biological processes but they are poorly understood compared to active kinases. Eight putative pseudokinases have been predicted in Plasmodium species.
Bénédicte Gnangnon, Aline Fréville, Katia Cailliau   +2 more
exaly   +6 more sources

Inhibition of Malaria Parasite Development by a Cyclic Peptide That Targets the Vital Parasite Protein SERA5 [PDF]

Infection and Immunity, 2008
ABSTRACTThe serine repeat antigen (SERA) proteins of the malaria parasitesPlasmodiumspp. contain a putative enzyme domain similar to that of papain family cysteine proteases. InPlasmodium falciparumparasites, more than half of the SERA family proteins, including the most abundantly expressed form, SERA5, have a cysteine-to-serine substitution within ...
Walter D Fairlie, Paul R Gilson, Geoffrey I Mcfadden   +2 more
exaly   +3 more sources

Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens. [PDF]

PLoS Comput Biol, 2022
Investigation of the diversity of malaria parasite antigens can help prioritize and validate them as vaccine candidates and identify the most common variants for inclusion in vaccine formulations.
Naung MT, Martin E, Munro J, Mehra S, Guy AJ, Laman M, Harrison GLA, Tavul L, Hetzel M, Kwiatkowski D, Mueller I, Bahlo M, Barry AE.   +12 more
europepmc   +3 more sources

Characterization of sequence diversity in Plasmodium falciparum SERA5 from Indian isolates

Asian Pacific Journal of Tropical Disease, 2015
Abstract Objective To characterize the sequence diversity of blood-stage Plasmodium falciparum serine repeat antigen-5 (PfSERA5) which is lacking in a malaria-endemic country like India. Methods In this study, parasitic DNA was obtained from field isolates collected from various geographic regions.
Vidya Rajesh
exaly   +2 more sources

Serine Repeat Antigen (SERA5) Is Predominantly Expressed among the SERA Multigene Family of Plasmodium falciparum, and the Acquired Antibody Titers Correlate with Serum Inhibition of the Parasite Growth [PDF]

Journal of Biological Chemistry, 2002
The Plasmodium falciparum serine repeat antigen (SERA) is one of the blood stage malaria vaccine candidates. The malaria genome project has revealed that SERA is a member of the SERA multigene family consisting of eight SERA homologues clustered on chromosome 2 and one SERA homologue on chromosome 9. Northern blotting and real time quantitative reverse
Hiroyuki Matsuoka, Nirianne Marie Palacpac, Toshihiro Horii   +2 more
exaly   +3 more sources

Safety, immunogenicity, and cross-species protection of aplasmid DNA encoding Plasmodium falciparum SERA5polypeptide, microbial epitopes and chemokine genes in miceand olive baboons

Journal of Biomedical Research, 2017
Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of strain-transcending malarial vaccines. The present study sought to determine safety, immunogenicity and cross-species efficacy ofPlasmodium falciparum serine repeat antigen 5 polypeptide co-expressed with epitopes of Bacille-Calmette Guerin (BCG ...
Onkoba, N, Mumo, RM, Ochanda, H, Omwandho, C, Ozwara, HS, Egwang, TG   +5 more
exaly   +4 more sources

Genetic Diversity in C-terminal of SERA5 Gene in the Blood Stage of Human Isolates of Plasmodium vivax in Sistan and Baluchistan, Iran

Iranian Journal of Parasitology, 2018
Background: Vivax malaria is more prevalent in the malarious areas of Iran, which makes vaccine research a high priority. Serine Repeat Antigens (SERA) have essential role in the parasite life cycle and high expression profiles of PvSERA5 make it ...
Ahmad ABOLGHAZI, Aliehsan HEIDARI, Vahideh MOIN-VAZIRI, Ali HAGHIGHI, Seyyed Javad SEYYED TABAEI, Hossein KESHAVARZ, Saeedeh SHOJAEE   +6 more
doaj   +2 more sources

Genetic Characterization of C-Terminal Region of SERA5 Gene in Isolates of Plasmodium vivax in Southwestern Iran

Infection, Epidemiology and Microbiology, 2022
Gholamreza Shokoohi, Aminallah Saadatnia, Ahmad Abolghazi   +2 more
exaly   +2 more sources

Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: a phase 1b randomised, controlled, double-blinded, age de-escalation trial

Frontiers in Immunology, 2023
BackgroundBK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to aluminium hydroxide gel and reconstituted, prior to administration, with synthetic ...
Alphonse Ouédraogo, Edith Christiane Bougouma, Nirianne Marie Q. Palacpac, Sophie Houard, Issa Nebie, Jean Sawadogo, Gloria D. Berges, Issiaka Soulama, Amidou Diarra, Denise Hien, Amidou Z. Ouedraogo, Amadou T. Konaté, Seni Kouanda, Akira Myoui, Sachiko Ezoe, Sachiko Ezoe, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Takanobu Sato, Flavia D’Alessio, Odile Leroy, Alfred B. Tiono, Simon Cousens, Toshihiro Horii, Sodiomon B. Sirima   +25 more
doaj   +1 more source

Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children

Frontiers in Immunology, 2022
BackgroundA blood-stage vaccine targeting the erythrocytic-stages of the malaria parasite Plasmodium falciparum could play a role to protect against clinical disease. Antibodies against the P.
Edith Christiane Bougouma, Edith Christiane Bougouma, Nirianne Marie Q. Palacpac, Alfred B. Tiono, Alfred B. Tiono, Issa Nebie, Issa Nebie, Alphonse Ouédraogo, Alphonse Ouédraogo, Sophie Houard, Masanori Yagi, Sam Aboubacar Coulibaly, Amidou Diarra, Amidou Diarra, Takahiro Tougan, Amidou Z. Ouedraogo, Amidou Z. Ouedraogo, Issiaka Soulama, Nobuko Arisue, Jean Baptiste Yaro, Flavia D’Alessio, Odile Leroy, Simon Cousens, Toshihiro Horii, Sodiomon B. Sirima, Sodiomon B. Sirima   +25 more
doaj   +1 more source