Inhibitory potential of prodomain of Plasmodium falciparum protease serine repeat antigen 5 for asexual blood stages of parasite. [PDF]
PLoS ONE, 2012 Plasmodium falciparum serine repeat antigen 5 (SERA5) is a target for both drug and vaccine intervention against malaria. SERA5 is secreted in the parasitophorous vacuole where it is proteolytically processed before schizont rupture.
Asrar Alam, Virander S Chauhan
doaj +1 more source
In Silico Gene Regulatory Network of the Maurer’s Cleft Pathway in Plasmodium falciparum [PDF]
, 2015 The Maurer’s clefts (MCs) are very important for the survival of Plasmodium falciparum within an infected cell as they are induced by the parasite itself in the erythrocyte for protein trafficking.
Adebiyi, Ezekiel +3 more
core +6 more sources
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. [PDF]
, 2020 A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent ...
Cheung, Andrea L +25 more
core +5 more sources
A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress. [PDF]
, 2017 : Regulated exocytosis by secretory organelles is important for malaria parasite invasion and egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are extensively proteolytically processed both pre- and postexocytosis ...
Blackman, MJ +11 more
core +2 more sources
Molecular determinants of binding to the Plasmodium subtilisin-like protease 1. [PDF]
, 2013 PfSUB1, a subtilisin-like protease of the human malaria parasite Plasmodium falciparum, is known to play important roles during the life cycle of the parasite and has emerged as a promising antimalarial drug target.
Arastu-Kapur S. +46 more
core +1 more source
The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress. [PDF]
, 2018 Apicomplexa are obligate intracellular parasites that actively invade, replicate within, and egress from host cells. The parasite actinomyosin-based molecular motor complex (often referred to as the glideosome) is considered an important mediator of ...
Baker, David A +5 more
core +1 more source
Outdoor Electroluminescence Acquisition Using a Movable Testbed [PDF]
, 2018 The experimentation with a movable outdoor electroluminescence (EL) testbed is performed in this work. For EL inspections of PV power plants, the fastest scenario will include the use of unmanned aerial vehicle (UAV) performing image acquisition in ...
Benatto, Gisele Alves dos Reis +15 more
core +2 more sources
EBioMedicine, 2019 Background: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa.
Andriy Derkach +19 more
doaj +1 more source
The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. [PDF]
, 2017 Merozoites of the protozoan parasite responsible for the most virulent form of malaria, Plasmodium falciparum, invade erythrocytes. Invasion involves discharge of rhoptries, specialized secretory organelles. Once intracellular, parasites induce increased
Aurrecoechea +68 more
core +2 more sources
Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids [PDF]
, 2018 Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide.
Ascencio, Mariano E. +5 more
core +4 more sources