Results 31 to 40 of about 10,855,625 (286)

Étude comparative Canada/États-Unis sur la philanthropie subventionnaire fondée sur le lieu

Canadian Journal of Nonprofit and Social Economy Research
L’objet du présent article est de présenter les principaux résultats d’une démarche de recherche réalisée entre 2019 et 2022 avec l’appui du Conseil de recherche en sciences humaines du Canada (CRSH).
Jean-Marc Fontan, Maria Martinez-Cosio, Joshua Newton, Nancy Pole, Mirle Rabinowitz-Bussell   +4 more
doaj   +1 more source

Anopheline species composition and the 1014F-genotype in different ecological settings of Burkina Faso in relation to malaria transmission

Malaria Journal, 2019
Background A three-year longitudinal study was conducted in four sentinel sites from different ecological settings in Burkina Faso, between 2008 and 2010 to identify longitudinal changes in insecticide resistance within Anopheles gambiae complex species ...
Alphonse Traoré, Athanase Badolo, Moussa W. Guelbeogo, Antoine Sanou, Mafalda Viana, Luca Nelli, Soumanaba Zongo, Hyacinthe K. Toé, Alfred S. Traoré, Hilary Ranson, N’Falé Sagnon   +10 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Les droits et libertés du numérique. Étude comparée en droits français et américain : éléments de méthode d’une thèse de droit comparé

Droit Public Comparé
Cet article propose de retracer la méthodologie comparative utilisée dans le cadre du travail de thèse sur les droits et libertés du numérique comme droits fondamentaux en voie d’élaboration.
Rym Fassi-Fihri
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The Sticky Resting Box, a new tool for studying resting behaviour of Afrotropical malaria vectors

Parasites & Vectors, 2014
Background Monitoring densities of adult mosquito populations is a major challenge in efforts to evaluate the epidemiology of mosquito-borne diseases, and their response to vector control interventions.
Marco Pombi, Wamdaogo M Guelbeogo, Katharina Kreppel, Maria Calzetta, Alphonse Traoré, Antoine Sanou, Hilary Ranson, Heather M Ferguson, N’Fale Sagnon, Alessandra della Torre   +9 more
doaj   +1 more source