Results 81 to 90 of about 392,246 (283)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Yiqi Huoxue recipe ameliorates diabetic nephropathy by mediating VAPB–PTPIP51 complex to activate autophagy and regulate MAM contact

Frontiers in Nutrition
BackgroundDiabetic nephropathy (DN), a major complication of diabetes mellitus (DM), poses a high mortality and a global health burden. Mitochondria-associated endoplasmic reticulum membranes (MAMs) and mediated autophagy are regarded as the crucial ...
Linghao Dai, Mengyi Wang, Bo Wang, Haowei Liang, Yang Guan, Zhongyan Du, Hui Wang, Hui Wang, Hui Wang   +8 more
doaj   +1 more source

FROM A MONOMODAL RECIPE TO A MULTIMODAL OFFER. A TEXTOLOGICAL AND MEDIOLINGUISTIC APPROACH

Humanities and Social Sciences, 2018
Not so long ago recipes were included in 'obvious' text types functioning „unproblematically in the sphere of everyday life”[1], because their relatively uncomplicated structure did not cause any difficulties with recognition and qualification, or with ...
Anna HANUS, Dorota KACZMAREK
doaj   +1 more source

Simulating galactic outflows with kinetic supernova feedback

, 2008
Feedback from star formation is thought to play a key role in the formation and evolution of galaxies, but its implementation in cosmological simulations is currently hampered by a lack of numerical resolution.
Aguirre, Balogh, Brook, Chabrier, D'Ercole, Dubois, Ferland, Fujita, Haardt, Hernquist, Katz, Kawata, Kay, Kennicutt, Kim, Mac Low, Marri, Martin, Mihos, Mori, Navarro, Navarro, Oppenheimer, Ponman, Puche, Rupke, Salpeter, Scannapieco, Schaye, Schaye, Schwartz, Shapley, Silich, Silich, Sommer-Larsen, Springel, Springel, Springel, Springel, Stanimirovic, Staveley-Smith, Stinson, Thacker, Veilleux, Walter, White, Yepes   +46 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Rationale for the development of an innovative product with the addition of hydrobionts within the framework of the ESG challenges

Новые технологии
At present food industry must meet the global challenges that we face. The first one is hunger; the population continues to grow, it is necessary to meet nutritional needs by increasing funding for the development of agricultural areas and introducing ...
M. V. Zakoptelova, J. S. Boitsova
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Transverse momentum correlations of quarks in recursive jet models

, 2016
In the symmetric string fragmentation recipe adopted by PYTHIA for jet simulations, the transverse momenta of successive quarks are uncorrelated. This is a simplification but has no theoretical reason.
Artru, X., Belghobsi, Z., Redouane-Salah, E.   +2 more
core   +3 more sources

Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke: A Multicenter Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma fibrinogen is essential in thrombosis and fibrinolysis, yet its dynamic changes pre‐ and post‐intravenous thrombolysis (IVT) for predicting brain injury severity and prognosis in acute ischemic stroke (AIS) patients remain unclear.
Wenhai Zhai, Yang Qu, Reziya Abuduxukuer, Kejia Zhang, Peng Zhang, Xin Tang, Huaimei Zhang, Lijuan Wang, Lichong Yang, Shuangxu Tan, Zhimei Yuan, Ce Han, Lili He, Yuping Zheng, Fenglan Zhao, Lijie Guo, Ligang Jiang, Jinfeng Li, Yongfei Jiang, Xuexia Zou, Dan Xu, Han Xu, Xiaojia Wang, Yingbin Qi, Xuefeng Hu, Yu Zhang, Zhen‐Ni Guo, Hang Jin, on behalf of the Biomarkers of Brain Injury Investigator Study Group   +28 more
wiley   +1 more source