Results 151 to 160 of about 1,275,682 (317)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The Geographical Allocation Pattern of Spanish Official Development Assistance [PDF]

The geographical allocation of Spanish aid has been little studied, despite the fact that it is unusually concentrated on middle-income countries. This paper sets out a model of Spanish ODA policy based on an integrated approach reflecting recipient ...
Sergio Tezanos Vazquez (ICEI and QEH)
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Canadian Transplant Candidates' and Recipients' Perspectives on Mandatory Vaccination and Access to Transplantation: A Qualitative Study. [PDF]

Clin Transplant
Cochran-Mavrikakis SL, Sancho C, Affdal A, Gallego FB, Malo MF, Ducharme L, Foccroulle-Bussières S, An L, Poirier C, Huard G, Tousignant N, Fortin MC.   +11 more
europepmc   +1 more source

Chicana Schism: The Relationship Between Chicana Feminist and Chicana Feminist Lesbians [PDF]

, 2001
Saavedra,, Yvette, Cervantes Undergraduate Recipient
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Donor Bladder Inclusion in Kidney Transplantation: A Review of the Literature and our Clinical Experience. [PDF]

Curr Urol Rep
Ciancio G, Gaynor JJ, Gonzalez J, Nava HO, Gaynor M, Abraham ASM, Kim Y, Sageshima J, Morsi M.   +8 more
europepmc   +1 more source

La Planta e s la Vida: Plants and Curanderismo on San Antonio’s Westside [PDF]

, 2001
de la Portilla,, Elizabeth, Cervantes Graduate Recipient
core   +1 more source