Results 31 to 40 of about 118,583 (315)
Crossing Boundaries, Creating Change: A Competence Framework for Bridge-Builders
Baltic Journal of Sport and Health SciencesPurpose: This study aims to develop a comprehensive competence framework for professionals facilitating cross-sector collaboration, innovation, and systemic change across organisational, disciplinary, and cultural boundaries. It addresses the current gap
Robert Ovbiagbonhia +3 more
doaj +1 more source
Revista Iberoamericana de Estudios de Desarrollo, 2021 In the context of the current systemic crisis, neoliberal capitalism is widely questioned for its unsustainability, but there is a lack of proposals from other epistemological and ontological frameworks that allow the construction of real alternatives of
Patricia Viera-Bravo
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Effects of violet light exposure on aging dogs: a pilot study
Frontiers in Veterinary ScienceAging in dogs is known to induce various physical and brain alterations similar to dementia in humans. Concurrently with the recent extension of canine life expectancy, these age-related changes have imposed growing burdens on both dogs and their owners,
Kana Miyamoto +9 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Systems, 2022 In this study, we constructed a tripartite evolutionary game model for a large-scale enterprise (A), a small-scale enterprise (B), and a government, based on finite rationality and information asymmetry.
Min Wang +4 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Effects of Inequality on Trust and Reciprocity: An Experiment With Real Effort
Frontiers in Psychology, 2021 The purpose of this paper is analyzing whether trust and reciprocity are affected by how rich the partner is or how well the partner performed several tasks with real effort. A trust game (TG) experiment is designed with three treatments.
Amalia Rodrigo-González +3 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source