Results 71 to 80 of about 1,401,477 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Contribution of auditory working memory to speech understanding in mandarin-speaking cochlear implant users.

PLoS ONE, 2014
PurposeTo investigate how auditory working memory relates to speech perception performance by Mandarin-speaking cochlear implant (CI) users.MethodAuditory working memory and speech perception was measured in Mandarin-speaking CI and normal-hearing (NH ...
Duoduo Tao, Rui Deng, Ye Jiang, John J Galvin, Qian-Jie Fu, Bing Chen   +5 more
doaj   +1 more source

Context reinstatement in recognition: memory and beyond [PDF]

, 2014
Context effects in recognition tests are twofold. First, presenting familiar contexts at a test leads to an attribution of context familiarity to a recognition probe, which has been dubbed ‘context-dependent recognition’.
Bancroft, Bodner, Bulevich, Busey, Clark, Dando, Dodson, Eich, Eich, Evans, Fisher, Geiselman, Godden, Gruppuso, Gruppuso, Hanczakowski, Hanczakowski, Higham, Higham, Higham, Hockley, Hockley, Hockley, Jaeger, Jou, Katarzyna Zawadzka, Kerr, Koriat, Koriat, Koriat, Laura Coote, Maciej Hanczakowski, Macken, Mickes, Milne, Mueller, Murnane, Murnane, Murnane, Murnane, Reder, Reinitz, Reinitz, Smith, Smith, Smith, Sporer, Tibon, Watkins, Winograd   +49 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task

Frontiers in Behavioral Neuroscience, 2022
Episodic memory depends on the recollection of spatial and temporal aspects of past experiences in which the hippocampus plays a critical role. Studies on hippocampal lesions in rodents have shown that dentate gyrus (DG) and CA3 are necessary to detect ...
Lívia Neves, Bruno Lobão-Soares, Bruno Lobão-Soares, Ana Paula de Castro Araujo, Ana Paula de Castro Araujo, Alan Michel Bezerra Furtunato, Izabela Paiva, Nicholy Souza, Anne Kelly Morais, George Nascimento, Elaine Gavioli, Elaine Gavioli, Adriano Bretanha Lopes Tort, Flávio Freitas Barbosa, Flávio Freitas Barbosa, Hindiael Belchior, Hindiael Belchior   +16 more
doaj   +1 more source

MAO-A and the EEG Recognition Memory Signal in Left Parietal Cortex [PDF]

, 2014
A key part of episodic memory, or memory for the events of our lives, is recognition memory. Recognition memory is the ability to remember previously encountered stimuli.
Curran, Tim, Fisher, Claire M, Nyhus, Erika, Ross, Robert   +3 more
core   +1 more source

Increased susceptibility to proactive interference in adults with dyslexia? [PDF]

, 2015
Recent findings show that people with dyslexia have an impairment in serial-order memory. Based on these findings, the present study aimed to test the hypothesis that people with dyslexia have difficulties dealing with proactive interference (PI) in ...
Arnaud Szmalec, Bogaerts L., Brus B. T., Dekker R., Evy Woumans, Hachmann W. M., Hebb D., Louisa Bogaerts, Mike P.A. Page, Page M. P. A., Snowling M. J., Surprenant A. M., van den Bos K. P., Wibke M. Hachmann, Wouter Duyck   +14 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Emotional memory for musical excerpts in young and older adults.

Frontiers in Aging Neuroscience, 2015
The emotions evoked by music can enhance recognition of excerpts. It has been suggested that memory is better for high than for low arousing music (Eschrich et al., 2005; Samson et al., 2009), but it remains unclear whether positively (Eschrich et al ...
Irene eAlonso, Irene eAlonso, Irene eAlonso, Delphine eDellacherie, Delphine eDellacherie, Séverine eSamson, Séverine eSamson   +6 more
doaj   +1 more source