Results 171 to 180 of about 1,379,490 (255)

Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment. [PDF]

Toxins (Basel), 2022
Valencia-Martínez H, Olamendi-Portugal T, Restano-Cassulini R, Serrano-Posada H, Zamudio F, Possani LD, Riaño-Umbarila L, Becerril B.   +7 more
europepmc   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system. [PDF]

EBioMedicine, 2021
Niborski LL, Potenza M, Chirivi RGS, Simonetti L, Ossowski MS, Grippo V, May M, Staquicini DI, Parodi-Talice A, Robello C, Comini MA, Alonso GD, Raats JMH, Gómez KA.   +13 more
europepmc   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Humoral immune response associated with Lyme borreliosis in nonhuman primates: analysis by immunoblotting and enzyme-linked immunosorbent assay with sonicates or recombinant proteins

, 2002
The immune response to Borrelia burgdorferi, the causative agent of Lyme disease, is complex. We studied the immunoglobulin M (IgM) and IgG antibody response to N40Br, a sensu stricto strain, in the rhesus macaque-(nonhuman primate [NHP]) model of ...
E. Hodzic, S. Barthold, Or Recombinant Proteins   +2 more
core  

Potential Diagnostic and Research Applications of a Recombinant Antibody Directed Against Ferrated Triacetylfusarinine C from <i>Aspergillus fumigatus</i>. [PDF]

J Fungi (Basel)
Dwyer M, Owens RA, Garcia Revuelto C, Walshe KG, Murphy CM, Moloney NM, Doyle S.   +6 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAF^V600E-Associated Mitochondrial Division in Cancer. [PDF]

Antibodies (Basel)
Nizard ST, Chen Y, Serasinghe MN, Fernandez-Rodriguez R, Shultz KD, Khatun J, Mendoza A, Gelles JD, Henao-Martinez JF, Abraham-Enachescu I, Noman MAA, Bayiokos SG, Duty JA, Meehan S, Skobe M, Chipuk JE.   +15 more
europepmc   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Improving recombinant antibody production using FcBAR: An in situ approach to detect and amplify protein-protein interactions. [PDF]

Metab Eng
Wu MYM, Rocamora F, Samoudi M, Robinson CM, Kuo CC, Pristovšek N, Grav LM, Kildegaard HF, Lee GM, Campos AR, Lewis NE.   +10 more
europepmc   +1 more source