Results 101 to 110 of about 2,843,513 (257)

Humoral immune response associated with Lyme borreliosis in nonhuman primates: analysis by immunoblotting and enzyme-linked immunosorbent assay with sonicates or recombinant proteins

, 2002
The immune response to Borrelia burgdorferi, the causative agent of Lyme disease, is complex. We studied the immunoglobulin M (IgM) and IgG antibody response to N40Br, a sensu stricto strain, in the rhesus macaque-(nonhuman primate [NHP]) model of ...
E. Hodzic, S. Barthold, Or Recombinant Proteins   +2 more
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Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin Type 2 receptor [PDF]

, 2012
The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor.
Nicklin Stuart A., Almalik Abdulaziz, Bruno M D C Godinho, Flores-Muñoz Monica, Flores-Muñoz, M., Almalik, A., Nicklin, S.A., Monica Flores-Muñoz, Stuart A Nicklin, Abdulaziz Almalik, Godinho, B.M.D.C., Godinho Bruno M. D. C.   +11 more
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Self‐Assembled Hybrid Cell‐Enzyme Materials for Gas‐Powered Biocatalysis

Advanced Functional Materials, EarlyView.
Integrating living cells with programmable enzyme networks enables hybrid materials that convert gaseous feedstocks into chemical reducing power. These gas‐powered catalytic beads operate as modular, recyclable platforms for adaptive biocatalysis and sustainable synthesis.
Marius Stoeckle, Kersten S. Rabe, Christof M. Niemeyer   +2 more
wiley   +1 more source

Fusion to green fluorescent protein improves expression levels of Theileria parva sporozoite surface antigen p67 in insect cells [PDF]

, 2002
East Coast fever (ECF) is a fatal disease of cattle caused by the protozoan parasite Theileria parva. The development of a subunit vaccine, based on the sporozoite-specific surface antigen p67, has been hampered by difficulties in achieving high-level ...
Kaba, S.A., Nene, V., Musoke, A.J., Vlak, J.M., Oers, M.M., van   +4 more
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An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines [PDF]

, 2012
Monoclonal antibodies are commercially important, high value biotherapeutic drugs used in the treatment of a variety of diseases. These complex molecules consist of two heavy chain and two light chain polypeptides covalently linked by disulphide bonds ...
Martin, Elaine B., C Mark Smales, Sarah K. Spurgeon (128819), Mead, Emma J., Emma J. Mead (128810), Smales, C. Mark, Chiverton, Lesley M., Smales, Christopher Mark, Elaine B. Martin (128823), C. Mark Smales (128831), Spurgeon Sarah K., Spurgeon, Sarah K., Montague, Gary A.; id_orcid, Montague, Gary A, Smales C. Mark, Montague, Gary A., von der Haar Tobias, Smales, C Mark, Emma J Mead, Sarah K Spurgeon, Gary A Montague, Martin Elaine B., Gary A. Montague (128826), von der Haar, Tobias, Mead, Emma J, Lesley M. Chiverton (128814), Chiverton Lesley M., Elaine B Martin, Tobias von der Haar, Tobias von der Haar (80575), Mead Emma J., Montague Gary A., Lesley M Chiverton   +32 more
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Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Cellular tropism and cell-to-cell fusion properties of the infectious bronchitis virus spike glycoprotein [PDF]

There are numerous vaccines available for the control of infectious bronchitis virus (IBV) in poultry, however protection is short-lived and poorly cross-protective between strains.
Bickerton, Erica Jane
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