Results 111 to 120 of about 282,766 (336)
Bidirectional Hierarchical Protein Multi-Modal Representation Learning [PDF]
arXivProtein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based tasks. However, pLMs lack structural information. Conversely, graph neural networks (GNNs) designed to leverage 3D
arxiv
r-Sm14 - pRSETA efficacy in experimental animals
Memorias do Instituto Oswaldo Cruz, 2001 Previous studies carried out with Sm14 in experimental vaccination against Schistosoma mansoni or Fasciola hepatica infections were performed with recombinant Sm14 (rSm14) produced in Escherichia coli by the pGEMEX system (Promega).
Celso Raul Romero Ramos +9 more
doaj +1 more source
Soluble FasR ligand-binding domain: high-yield production of active fusion and non-fusion recombinant proteins using the baculovirus/insect cell system [PDF]
, 1998 Jérôme Mahiou +3 more
openalex +1 more source
Advanced Science, EarlyView.A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang +16 more
wiley +1 more source
Advanced Science, EarlyView.USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang +16 more
wiley +1 more source
Correlation of serum IgG antibodies to recombinant P0 fusion protein with IgG antibodies to carboxyl‐terminal 22 synthetic peptides and carboxyl‐terminal 22 amino acid‐deleted recombinant P0 fusion protein in patients with systemic lupus erythematosus [PDF]
, 1997 Taku Yoshio +7 more
openalex +1 more source
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Advanced Science, EarlyView.This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao +15 more
wiley +1 more source
Advanced Science, EarlyView.Lactobacillus johnsonii and its associated purine metabolite inosine not only restrict systemic B cell differentiation, but also contribute to immune cell infiltration in the kidneys, thereby serving dual functions in mitigating the progression of systemic lupus erythematosus (SLE).
Lingyu Gao +15 more
wiley +1 more source
A Protein Structure Prediction Approach Leveraging Transformer and CNN Integration [PDF]
arXivProteins are essential for life, and their structure determines their function. The protein secondary structure is formed by the folding of the protein primary structure, and the protein tertiary structure is formed by the bending and folding of the secondary structure.
arxiv
Advanced Science, EarlyView.This study explores the structural heterogeneity and evolutionary adaptations of heteromultimeric bacterioferritins. Hetero‐Bfrs, evolved from either a homo‐Bfr or Ftn by gene duplications, differ from homo‐Bfrs substantially in the mechanisms underpinning iron oxidation and reduction despite high similarity in overall structure.
Yingxi Li +5 more
wiley +1 more source