Results 241 to 250 of about 282,766 (336)

Targeted release of a bispecific fusion protein SIRPα/Siglec-10 by oncolytic adenovirus reinvigorates tumor-associated macrophages to improve therapeutic outcomes in solid tumors. [PDF]

J Immunother Cancer
Zhang Y, He B, Zou P, Wu M, Wei M, Xu C, Dong J, Wei J.   +7 more
europepmc   +1 more source

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

Advanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao, Siwen Chen, Hua Chao, Zihao Li, Hao Yang, Dongying Chen, Sifang Li, Shuai Zhang, Jingyu Zhang, Jianru Wang, Zemin Li, Xiang Li, Zhongping Zhan, Tangming Guan, Yiwen Zhang, Wende Li, Hui Liu   +16 more
wiley   +1 more source

Antiviral activity of an ACE2-Fc fusion protein against SARS-CoV-2 and its variants. [PDF]

PLoS One
Bermúdez-Abreut E, Fundora-Barrios T, Hernández Fernández DR, Noa Romero E, Fraga-Quintero A, Casadesús Pazos AV, Fernández-Marrero B, Plasencia Iglesias CA, Clavel Pérez M, Sosa Aguiar K, Sánchez-Ramírez B, Hernández T.   +11 more
europepmc   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Expression of an epidermal growth factor-transdermal peptide fusion protein in <i>Arabidopsis thaliana</i> and its therapeutic effects on skin barrier repair. [PDF]

Front Plant Sci
Yu G, Lin S, Huang X, Gao S, Song C, Khalilov F, Chen Q, Issaro N, Xiao J, Xu X, Wang J, Zhao W, Wang Y, Xu N.   +13 more
europepmc   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Rab10 regulates neuropeptide release by maintaining Ca²⁺ homeostasis and protein synthesis. [PDF]

Elife
Dong J, Chen M, van Weering JRT, Li KW, Smit AB, Toonen RF, Verhage M.   +6 more
europepmc   +1 more source

Novel Bivalent mRNA‐LNP Vaccine for Highly Effective Protection against Pneumonic Plague

Advanced Science, EarlyView.
The study investigates mRNA‐lipid nanoparticle vaccines targeting Yersinia pestis, the causative agent of plague. Combined F1+LcrV mRNA vaccination elicited robust immune responses and protected mice against virulent wild‐type and atypical strains.
Uri Elia, Yinon Levy, Hila Cohen, Ayelet Zauberman, David Gur, Inbal Hazan‐Halevy, Moshe Aftalion, Shani Benarroch, Erez Bar‐Haim, Orit Redy‐Keisar, Ofer Cohen, Dan Peer, Emanuelle Mamroud   +12 more
wiley   +1 more source

Nanobody-mediated targeting of Plasmodium falciparum PfPIMMS43 can block malaria transmission in mosquitoes. [PDF]

Commun Biol
Ukegbu CV, Mohamed M, Hoermann A, Qin Y, Kweyamba PA, Lwetoijera DW, Windbichler N, Moore S, Christophides GK, Vlachou D.   +9 more
europepmc   +1 more source

Non‐Respiratory Extracellular Electron Transfer Competes with Nitrogenase for Electrons in Rhodopseudomonas Palustris

Advanced Science, EarlyView.
This study develops a photosynthetic bioelectrochemical nitrogen fixation system for simultaneous nitrogen fixation and current generation using Rhodopseudomonas palustris. Notably, extracellular electron transfer (EET) serves as a redox balancing strategy, suppressing nitrogen fixation by competing with nitrogenase for electrons.
Xuewen Liu, Panqing Qi, Weipeng Fan, Wuyang Liu, Xingjiang Li, Yong Nie, Xiao‐Lei Wu   +6 more
wiley   +1 more source